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Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion

DOI :

10.3791/63529-v

9:56 min

February 11th, 2022

February 11th, 2022

1,943 Views

1Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham

TGT surface is an innovative platform to study growth factor-integrin crosstalk. The flexible probe design, specificity of the adhesion ligand, and precise modulation of stimulation conditions allow robust quantitative assessments of EGFR-integrin interplay. The results highlight EGFR as a 'mechano-organizer' tuning integrin mechanics, influencing focal adhesion assembly and cell spreading.

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Tension Gauge Tether Probes

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