A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

3.0K Views

•

07:02 min

•

July 15th, 2021

DOI :

10.3791/62694-v

July 15th, 2021

•

Rei Ukita¹, John W. Stokes¹, W. Kelly Wu¹, Jennifer Talackine¹, Nancy Cardwell¹, Yatrik Patel¹, Clayne Benson⁵, Caitlin T. Demarest¹, Erika B. Rosenzweig³, Keith Cook², Emily J. Tsai⁴, Matthew Bacchetta¹^,⁶

¹Department of Thoracic Surgery, Vanderbilt University Medical Center, ²Department of Biomedical Engineering, Carnegie Mellon University, ³Department of Pediatrics, Columbia University Medical Center, Columbia University Irving Medical Center, ⁴Department of Medicine, Columbia University Medical Center, Columbia University Irving Medical Center, ⁵Department of Anesthesiology, Vanderbilt University Medical Center, ⁶Department of Biomedical Engineering, Vanderbilt University

Summary

Explore More Videos

Pulmonary Hypertension

Right Ventricular Failure

Large Animal Model

RV Adaptation

Therapeutic Development

Pulmonary Artery Banding

Surgical Procedure

Finochietto Retractor

Mini Thoracotomy

Intraoperative Technique

Vascular Occluder

Intrapericardial Dissection

Right Ventricular Pressure Line

Sheep Model

Cardiovascular Research

Chapters in this video

0:04

Introduction

0:52

Operative Procedure

5:03

Chronic PA Banding (9-10 Weeks)

6:07

Results: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

6:37

Conclusion

Related Videos

11:49

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

20.3K Views

08:15

Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice

13.9K Views

14:21

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

14.0K Views

11:00

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

11.5K Views

12:30

Electric Cell-substrate Impedance Sensing for the Quantification of Endothelial Proliferation, Barrier Function, and Motility

57.4K Views

09:39

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways

7.9K Views

08:53

The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

12.4K Views

10:54

Tunable Hydrogels from Pulmonary Extracellular Matrix for 3D Cell Culture

11.5K Views

06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

3.8K Views

06:48

Three-Dimensional Echocardiographic Method for the Visualization and Assessment of Specific Parameters of the Pulmonary Veins

2.7K Views