JoVE Logo
Faculty Resource Center

Sign In

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

DOI :

10.3791/62952-v

September 30th, 2021

September 30th, 2021

4,399 Views

1Global Drug Discovery, Novo Nordisk A/S, 2Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 4Independent consultant, 5Catalyst Biosciences, 6Værløse Dyreklinik

The refined tail vein transection (TVT) bleeding model in anesthetized mice is a sensitive in vivo method for the assessment of hemophilic bleeding. This optimized TVT bleeding model uses blood loss and bleeding time as endpoints, refining other models and avoiding death as an endpoint.

-- Views

Related Videos

article

In Vivo 2-Photon Calcium Imaging in Layer 2/3 of Mice

article

Transverse Aortic Constriction in Mice

article

In situ Quantification of Pancreatic Beta-cell Mass in Mice

article

In vivo Electroporation of Morpholinos into the Regenerating Adult Zebrafish Tail Fin

article

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

article

Establishing a Diaphyseal Femur Fracture Model in Mice

article

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

article

Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

article

Author Spotlight: Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies

article

A Cryoinjury Model for Studying Skeletal Muscle Regeneration of the Caudal Peduncle in Adult Zebrafish

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved