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Characterization of Neuromuscular Junctions in Mice by Combined Confocal and Super-Resolution Microscopy

DOI :

10.3791/63032-v

11:03 min

December 8th, 2021

December 8th, 2021

2,409 Views

1Genethon, 91000, Evry, France, 2Université Paris-Saclay, Univ Evry, Inserm, Genethon, Integrare research unit UMR_S951, 91000, Evry, France, 3Ecole Pratique des Hautes Etudes, PSL Research University, 75014, Paris, France

This protocol describes a method for morphometric analysis of neuromuscular junctions by combined confocal and STED microscopy that is used to quantify pathological changes in mouse models of SMA and ColQ-related CMS.

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Neuromuscular Junctions

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