JoVE Logo
Faculty Resource Center

Sign In

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

DOI :

10.3791/63389-v

11:06 min

January 31st, 2022

January 31st, 2022

3,136 Views

1CN Bio Innovations Ltd

Drug-induced liver injury (DILI) is a major cause of drug failure. A protocol has been developed to accurately predict the DILI liability of a compound using a liver microphysiological system (MPS). The liver model uses the coculture of primary hepatic cells and translationally relevant endpoints to assess cellular responses to treatment.

Tags

Drug induced Liver Toxicity

-- Views

Related Videos

article

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

article

Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats

article

Improved Lipofuscin Models and Quantification of Outer Segment Phagocytosis Capacity in Highly Polarized Human Retinal Pigment Epithelial Cultures

article

A Precise and Quantifiable Method for Collecting Hemolymph from Small Arthropods

article

Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells

article

Detection of Mitophagy in Caenorhabditis elegans and Mammalian Cells Using Organelle-Specific Dyes

article

Real-Time Measurements of Calcium and Contractility Parameters in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

article

Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

article

Direct Infusion Device for Molecule Delivery in Plants

article

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved