The authors have no acknowledgments.

All procedures performed in the studies involving human participants were conducted in accordance with the ethical standards of the Duke University Health System Institutional Research Committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The protocol was performed using input from several peer-reviewed papers in the academic literature2,13,14,15. Imaging was performed on the authors themselves for the normal images and as part of routine educational ultrasound scans done for teaching purposes for the positive images, with preceding verbal consent obtained as per institutional standards. The patients were selected based on certain criteria. Specifically, the inclusion criterion was any patient with hypotension, and the exclusion criterion was patient refusal to undergo an ultrasound exam.
1. Safety procedures
<ol>
	<li>Utilize nonsterile nitrile or latex gloves depending on the patient&#39;s allergies. Additional safety precautions may be required based on the clinical context. Please refer to the respective institution&#39;s infection control policies, and follow any precautions in place.</li>
</ol>
2. Probe selection
<ol>
	<li>For infants (i.e., children younger than 1 year of age), perform the sonographic evaluation of the IVC with either a low-frequency or high-frequency (&#62;5 MHz) ultrasound transducer, depending on the infant&#39;s body size. 
	&#8203;NOTE: IVC evaluation in infants is a specialized pediatric topic beyond the scope of this review. The remainder of this review solely focuses on imaging the IVC in individuals over 1 year of age.</li>
	<li>For individuals over 1 year of age, visualize the IVC with any low-frequency (&#8804;5 MHz) ultrasound transducer, such as a linear phased-array sector arc probe or curvilinear probe. 
	NOTE: The linear phased-array sector arc probe is commonly referred to as a phased-array probe. This term is misleading, since all modern ultrasound transducers use phasing to steer the ultrasound beam16,17. However, for the sake of brevity, throughout this review, we will use the term phased-array probe instead of linear phased-array sector arc probe.
	<ol>
		<li>The phased-array probe is the optimal probe for both main types of external cardiac ultrasound: transthoracic echocardiography (TTE) and focused cardiac ultrasound (FoCUS)18. When performing either TTE or FoCUS to evaluate the heart, continue using the phased-array transducer for the IVC portion of each exam rather than switching to another low-frequency probe.</li>
	</ol>
	</li>
</ol>
3. Machine preset
<ol>
	<li>Set the machine to the cardiology convention by using the Cardiac Preset function, which sets the indicator to the left of the screen. Set the screen refresh rate to &#62;20 Hz. 
	NOTE: The IVC evaluation can be performed in the Abdominal Mode. However, for the same points mentioned in step 2.2.1, it is far more convenient to utilize the same presets for both a FoCUS exam and a POCUS IVC exam.</li>
	<li>Set the mode to B-Mode (2-dimensional grayscale). Set the depth to 6-20 cm, depending on the depth of the IVC in each patient.</li>
</ol>
4. Scanning technique
<ol>
	<li>Apply ultrasound gel to the transducer.</li>
	<li>Obtain the anterior IVC short-axis (ANT IVC SAX) view.
	<ol>
		<li>Position the patient in the supine position with both hips flexed, if tolerated by the patient.</li>
		<li>Place the ultrasound probe centered on the patient&#39;s anterior midline just caudal to the xiphoid process in the coronal plane, with the transducer indicator mark pointing toward the patient&#39;s left (Figure 1).</li>
		<li>Adjust the depth so that the IVC and aorta appear in the middle third of the screen and the spine is visible (Video 1).</li>
		<li>For setting the axis, fan the ultrasound beam cranially or caudally until both the IVC and the abdominal aorta appear in the short-axis cross-section as rounded structures (Video 1).</li>
		<li>Decrease the gain until the blood in the IVC is either completely black or just a few specks of grey are visible (Video 1).</li>
		<li>Once all the settings are done, click on Acquire.</li>
	</ol>
	</li>
	<li>Obtain the anterior IVC long-axis (ANT IVC LAX) view.
	<ol>
		<li>Position the patient in the supine position with both hips flexed, if tolerated by the patient.</li>
		<li>Position the probe for obtaining the ANT IVC SAX view as described in step 4.2, center the view on the IVC, and rotate the ultrasound probe 90&#176; counterclockwise, without translating the probe, such that the probe&#39;s indicator faces cranially at the end of the rotation (Figure 2).</li>
		<li>Adjust the depth so that the IVC appears in the middle third of the screen and the liver tissue is visible deeper than the IVC (Video 2).</li>
		<li>For setting the axis, fan the ultrasound beam toward the patient&#39;s left or right until the IVC appears as a rectangular, intrahepatic structure spanning from cranial to caudal on the screen. (Video 2).</li>
		<li>Decrease the gain until the blood in the IVC is either completely black or just a few specks of grey are visible (Video 2).</li>
		<li>Once all the settings are done, click on Acquire.</li>
		<li>Optional: Quantify the IVC anterior-to-posterior (AP) diameter (Figure 3).
		<ol>
			<li>With a live image of the IVC optimized as per step 4.3.6, click on Freeze. Click on Caliper or Measure, depending on the machine&#39;s measurement button.</li>
			<li>Move the trackball to the anterior wall of the IVC approximately 1-2 cm caudal from the hepatic vein confluence. Click on Select.</li>
			<li>Move the trackball to the posterior wall of the IVC opposite the point in step 4.3.7.2, such that the line between the two points is roughly perpendicular to the long axis of the IVC. Click on Select, and then click on Acquire.</li>
		</ol>
		</li>
	</ol>
	</li>
	<li>Obtain the right lateral IVC long-axis (RL IVC LAX) view.
	<ol>
		<li>Position the patient in the supine position with the legs flat and the right arm moved away from the patient&#39;s side, either overhead or outstretched laterally, so as to allow access to the right flank.</li>
		<li>Place the probe transducer in the coronal plane with the indicator pointing cranially in the sixth or seventh right intercostal space just anterior to the right mid-axillary line (Figure 4).</li>
		<li>Adjust the depth so that the IVC appears in the middle third of the screen and the liver tissue is visible deeper than the IVC (Video 3).</li>
		<li>For setting the axis, fan the ultrasound beam anteriorly or posteriorly until the IVC is visualized as a rectangular, intrahepatic structure spanning from cranial to caudal on the screen (Video 3).</li>
		<li>Decrease the gain until the blood in the IVC is either completely black or just a few specks of grey are visible (Video 3). Click on Acquire.</li>
	</ol>
	</li>
	<li>Obtain the right lateral IVC short-axis (RL IVC SAX) view.
	<ol>
		<li>Continue positioning the patient supine with the legs flat and the right arm moved away from the patient&#39;s side, either overhead or outstretched laterally, so as to allow access to the right flank.</li>
		<li>Continue positioning the probe in the position used for obtaining the RL IVC LAX view (see step 4.4), center the view on the IVC, and rotate the ultrasound probe 90&#176; clockwise, without translating the probe, such that the probe&#39;s indicator faces anteriorly at the end of the rotation (Figure 5).</li>
		<li>Adjust the depth so that the IVC appears in the middle third of the screen and the liver tissue, aorta, and spine are all visible deeper than the IVC (Video 4).</li>
		<li>For setting the axis, fan the ultrasound beam cranially or caudally until the IVC and abdominal aorta are visible in the short-axis view as rounded structures (Video 4).</li>
		<li>Decrease the gain until the blood in the IVC is either completely black or just a few specks of grey are visible (Video 4). Click on Acquire.</li>
	</ol>
	</li>
</ol>

<ol>
	<li>Hashim, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+utility+of+point+of+care+ultrasonography+(POCUS).">The utility of point of care ultrasonography (POCUS).</a> Annals of Medicine and Surgery. 71, 102982 (2021).</li><li>Finnerty, N. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Inferior+vena+cava+measurement+with+ultrasound:+What+is+the+best+view+and+best+mode.">Inferior vena cava measurement with ultrasound: What is the best view and best mode.</a> The Western Journal of Emergency Medicine. 18 (3), 496-501 (2017).</li><li>Aslan, Y., Arslan, G., Saracoglu, K. T., Eler Cevik, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+effect+of+ultrasonographic+measurement+of+vena+cava+inferior+diameter+on+the+prediction+of+post-spinal+hypotension+in+geriatric+patients+undergoing+spinal+anaesthesia.">The effect of ultrasonographic measurement of vena cava inferior diameter on the prediction of post-spinal hypotension in geriatric patients undergoing spinal anaesthesia.</a> International Journal of Clinical Practice. 75 (10), 14622 (2021).</li><li>Vander Mullen, J., Wise, R., Vermeulen, G., Moonen, P. 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W., Kory, P. D., Arntfield, R. T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Development+of+a+fluid+resuscitation+protocol+using+inferior+vena+cava+and+lung+ultrasound.">Development of a fluid resuscitation protocol using inferior vena cava and lung ultrasound.</a> Journal of Critical Care. 31 (1), 96-100 (2016).</li><li>Ruge, M., Marhefka, G. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=IVC+measurement+for+the+noninvasive+evaluation+of+central+venous+pressure.">IVC measurement for the noninvasive evaluation of central venous pressure.</a> Journal of Echocardiography. 20 (3), 133-143 (2022).</li><li>Privratsky, J. R., Schroder, V. T., Hashmi, N., Bronshteyn, Y. 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G., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Guidelines+for+the+echocardiographic+assessment+of+the+right+heart+in+adults:+a+report+from+the+American+Society+of+Echocardiography+endorsed+by+the+European+Association+of+Echocardiography,+a+registered+branch+of+the+European+Society+of+Cardiology,+and+the+Canadian+Society+of+Echocardiography.">Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography.</a> Journal of the American Society of Echocardiography. 23 (7), 685-713 (2010).</li><li>Blehar, D. J., Resop, D., Chin, B., Dayno, M., Gaspari, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Inferior+vena+cava+displacement+during+respirophasic+ultrasound+imaging.">Inferior vena cava displacement during respirophasic ultrasound imaging.</a> Critical Ultrasound Journal. 4 (1), 18 (2012).</li><li>Kisslo, J., vonRamm, O. T., Thurstone, F. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cardiac+imaging+using+a+phased+array+ultrasound+system.+II.+Clinical+technique+and+application.">Cardiac imaging using a phased array ultrasound system. II. Clinical technique and application.</a> Circulation. 53 (2), 262-267 (1976).</li><li>vonRamm, O. T., Thurstone, F. 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The authors have nothing to disclose.

Even when properly imaged, information garnered from the IVC should not be the sole data point used for guiding treatment. The exact same IVC size and respirophasic changes can be seen in both normal states and in pathologic conditions. Therefore, the clinical context is critically important for guiding how to interpret the IVC data. Further, when using ultrasound to assess a patient&#39;s intravascular volume status, the published literature is mixed as to what thresholds of IVC size and respirophasic change accurately ...

Over the last several decades, the accessibility of point-of-care ultrasound (POCUS) has increased dramatically. Providers across medical disciplines can now integrate POCUS into their bedside exams and more readily identify important contributors to patients&#39; conditions1. For example, in acute care settings, one of the most important areas of focus is the assessment and management of volume status2. Inadequate fluid resuscitation can result in tissue hypoperfusion, end-organ dysfunction, and severe acid-base abnormalities. However, overzealous fluid administration is associated with worsened mortality3. The determination of volume status has primarily been accomplished using the combination&#160;of physical exam findings and dynamic hemodynamic measures, including pulse pressure variation, central venous pressure, and/or fluid challenges via either passive leg-raise testing or intravenous fluid boluses4. With the growing availability of POCUS devices, some providers are seeking to use ultrasound imaging to supplement these measures5. The sonographic assessment of the anterior-to-posterior dimension of the IVC and the respirophasic change in that dimension can assist in the assessment of right atrial pressure and, possibly, intravascular volume status6,7,8,9.
Notably, however, the relationship between IVC parameters (i.e., size and respirophasic change) and volume responsiveness is distorted in many common situations, including but not limited to, the following: (1) passively ventilated patients receiving either high positive end-expiratory pressure (PEEP) or low tidal volumes; (2) spontaneously breathing patients making either small or large respiratory effort; (3) lung hyperinflation; (4) conditions impairing venous return (e.g., right ventricular dysfunction, tension pneumothorax, cardiac tamponade, etc.); and (5) increased abdominal compart pressure10.
While the utility of IVC sonography as a standalone measure for assessing the intravascular volume status is debated5,10,11,12, there is no debate about the fact that its use as a diagnostic tool requires imaging in standardized ways and the ability to utilize alternative views when a single vantage point proves to be inadequate2. Toward this end, this manuscript defines the four sonographic views of the IVC, illustrates common sonographic pitfalls and how to avoid them, and provides examples of both typical and extreme IVC sonographic states. There are four views in which the IVC can be adequately visualized by transabdominal sonography: anterior short-axis, anterior long-axis, right lateral long-axis, and right lateral short-axis. The protocol below describes a standardized method of image acquisition.

<table><tbody><tr><td>Edge 1 ultrasound machine</td><td>SonoSite</td><td>n/a</td><td>Used to obtain all adequate and inadequate images/clips</td></tr></tbody></table>

image acquisition method for the sonographic assessment of the inferior vena cava

Over the past several decades, clinicians have incorporated several applications of diagnostic point-of-care ultrasound (POCUS) into medical decision-making. Among the applications of POCUS, imaging the inferior vena cava (IVC) is practiced by a wide variety of specialties, such as nephrology, emergency medicine, internal medicine, critical care, anesthesiology, pulmonology, and cardiology. Although each specialty uses IVC data in slightly different ways, most medical specialties, at minimum, attempt to use IVC data to make predictions about intravascular volume status. While the relationship between IVC sonographic data and intravascular volume status is complex and highly context-dependent, all clinicians should collect the sonographic data in standardized ways to ensure repeatability. This paper describes standardized IVC image acquisition including patient positioning, transducer selection, probe placement, image optimization, and the pitfalls and limitations of IVC sonographic imaging.&#160;This paper also describes the commonly performed anterior IVC long-axis view and three other views of the IVC that can each provide helpful diagnostic information when the anterior long-axis view is difficult to obtain or interpret.

Adequate exam 
There is no single caliber or respirophasic behavior of the IVC that can be considered universally normal in all circumstances. For instance, the IVC seen in Videos 1-4 and Figure 3 was imaged in a healthy, hydrated male experiencing no acute illness. However, notably, this patient&#39;s &#34;normal&#34; IVC has a relatively large AP diameter, &#62;2 cm in the ANT IVC LAX view, and shows minimal respiroph...

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Image Acquisition Method for the Sonographic Assessment of the Inferior Vena Cava

Point-of-care ultrasound evaluation of the inferior vena cava (IVC) is commonly utilized to identify, among other things, the volume status. Imaging should be performed systematically to ensure repeatability. This manuscript reviews the methods and pitfalls of sonographic IVC examination.

Over the past several decades, clinicians have incorporated several applications of diagnostic point-of-care ultrasound (POCUS) into medical ...

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Research

JoVE Journal

Medicine

3.3K Views.  Duke University School of Medicine. Point-of-care ultrasound evaluation of the inferior vena cava (IVC) is commonly utilized to identify, among other things, the volume status. Imaging should be performed systematically to ensure repeatability. This manuscript reviews the methods and pitfalls of sonographic IVC examination.

Video: Image Acquisition Method for the Sonographic Assessment of the Inferior Vena Cava

The Supraclavicular Fossa Ultrasound View for Central Venous Catheter Placement and Catheter Change Over Guidewire

The supraclavicular fossa ultrasound view can be useful for central venous catheter (CVC) placement. Venipuncture of the internal jugular veins (IJV) or subclavian veins is performed with a micro-convex ultrasound probe, using a neonatal abdominal preset with a probe frequency of 10 Mhz at a depth of 10-12 cm. Following insertion of the guidewire into the vein, the probe is shifted to the right supraclavicular fossa to obtain a view of the superior vena cava (SVC), right pulmonary artery and ascending aorta. Under real-time ultrasound view, the guidewire and its J-tip is visualized and pushed forward to the lower SVC. Insertion depth is read from guidewire marks using central venous catheter. CVC is then inserted following skin and venous dilation. The supraclavicular fossa view is most suitable for right IJV CVC insertion. If other insertion sites are chosen the right supraclavicular fossa should be within the sterile field. Scanning of the IJVs, brachiocephalic veins and SVC can reveal significant thrombosis before venipuncture. Misplaced CVCs can be corrected with a change over guidewire technique under real-time ultrasound guidance. In conjunction with a diagnostic lung ultrasound scan, this technique has a potential to replace chest radiograph for confirmation of CVC tip position and exclusion of pneumothorax. Moreover, this view is of advantage in patients with a non-p-wave cardiac rhythm were an intra-cardiac electrocardiography (ECG) is not feasible for CVC tip position confirmation. Limitations of the method are lack of availability of a micro-convex probe and the need for training.

The overall goal is to enable clinicians to insert a central venous catheter under real-time ultrasound guidance via the right supraclavicular fossa view of the lower part of the superior vena cava. This view is useful for different catheter insertion sites, thrombosis detection before insertion and ultrasound guided correction of misplaced catheters.

The supraclavicular fossa ultrasound view can be useful for central venous catheter (CVC) placement. Venipuncture of the internal jugular veins (IJV) or ...

Three-Dimensional Echocardiographic Method for the Visualization and Assessment of Specific Parameters of the Pulmonary Veins

The dimensions of the pulmonary veins are important parameters when planning pulmonary vein isolation (PVI), especially with the cryoballoon ablation technique. Acknowledging the dimensions and anatomical variations of the pulmonary veins (PVs) may improve the outcome of the intervention. Conventional 2D transoesophageal echocardiography can only provide limited data about the dimensions of the PVs; however, 3D echocardiography can further evaluate relevant diameters and areas of the PVs, as well as their spatial relationship to surrounding structures. In previous literature data, parameters influencing the success rate of PVI have already been identified. These are the left lateral ridge, the intervenous ridge, the ostial area of the PVs and the ovality index of the ostium. Proper imaging of the PVs by 3D echocardiography is a technically challenging method. One crucial step is the collection of images. Three individual transducer positions are necessary to visualize the important structures; these are the left lateral ridge, the ostium of the PVs and the intervenous ridge of the left and right PVs. Next, 3D images are acquired and saved as digital loops. These datasets are cropped, which result in the en face views displaying spatial relationships. This step can also be employed to determine the anatomical variations of the PVs. Finally, multiplanar reconstructions are created to measure each individual parameter of the PVs.
Optimal quality and orientation of the acquired images are paramount for the appropriate assessment of PV anatomy. In the present work, we examined the 3D visibility of the PVs and the suitability of the above method in 80 patients. The aim was to provide a detailed outline of the essential steps and potential pitfalls of PV visualization and assessment with 3D echocardiography.

The dimensions of the pulmonary veins (PV) are important parameters when planning pulmonary vein isolation. 2D transoesophageal echocardiography can only provide limited data about the PVs; however, 3D echocardiography can evaluate relevant diameters and areas of the PVs, as well as their spatial relationship to surrounding structures.

The dimensions of the pulmonary veins are important parameters when planning pulmonary vein isolation (PVI), especially with the cryoballoon ablation ...

Bioengineering

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Fluid retention is the most common risk factor for mortality and cardiovascular complications in patients with volume-overloaded disease states. The extent of diuresis or fluid removal is frequently determined by physical examination which is subject to inaccuracies.
Bedside ultrasound (US) is a portable tool that brings real-time diagnostic imaging to the patient's bedside. This versatile modality makes it possible for the clinician to investigate patients' extravascular and intravascular volume states. The extravascular volume, particularly in the case of pulmonary edema, can be quantitatively assessed by US of the anterior chest. Intravascular volume is estimated by visualizing the inferior vena cava (IVC) caliber. Taken together, the degree of extravascular lung water and the IVC caliber provide objective data that can guide the clinician to determine the level of diuresis needed to effectively yet safely treat pulmonary edema. 
The objective of this article is threefold: 1) to summarize the findings of previous studies on the efficacy of portable US to guide fluid management, 2) to describe a proposed ultrasound protocol to help guide fluid management, and 3) to elucidate techniques that address the measurement of intravascular and extravascular volumes using portable US.

We describe an imaging protocol that enables the clinician to visualize, in real-time, the patient&#39;s intravascular and extravascular space volumes and set diuresis and fluid removal parameters accordingly for the safe and efficient treatment of pulmonary edema.

Fluid retention is the most common risk factor for mortality and cardiovascular complications in patients with volume-overloaded disease states. The ...

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Longitudinal evaluations of critically ill patients by combinations of clinical examination, biochemical analysis and critical care ultrasonography (CCUS) may detect adverse events of interventions such as fluid overload at an early stage. The Simple Intensive Care Studies (SICS) is a research line that focuses on the prognostic and diagnostic value of combinations of clinical variables.
The SICS-I specifically focused on the use of clinical variables obtained within 24 h of acute admission for prediction of cardiac output (CO) and mortality. Its sequel, SICS-II, focuses on repeated evaluations during ICU admission. The first clinical examination by trained researchers is performed within 3 h after admission consisting of physical examination and educated guessing. The second clinical examination is performed within 24 h after admission and includes physical examination and educated guessing, biochemical analysis and CCUS assessments of heart, lungs, inferior vena cava (IVC) and kidney. This evaluation is repeated at days 3 and 5 after admission. CCUS images are validated by an independent expert, and all data is registered in an online secured database. Follow-up at 90 days includes registration of complications and survival status according to patient&#39;s medical charts and the municipal person registry. The primary focus of SICS-II is the association between venous congestion and organ dysfunction.
The purpose of publishing this protocol is to provide details on the structure and methods of this on-going prospective observational cohort study allowing answering multiple research questions. The design of the data collection of combined clinical examination and CCUS assessments in critically ill patients are explicated. The SICS-II is open for other centers to participate and is open for other research questions that can be answered with our data.

Structured protocols are necessary to provide answers on research questions in critically ill patients. The Simple Intensive Care Studies (SICS) provides an infrastructure for repeated measurements in critically ill patients including clinical examination, biochemical analysis and ultrasonography. SICS projects have specific focus but the structure is flexible to other investigations.

Longitudinal evaluations of critically ill patients by combinations of clinical examination, biochemical analysis and critical care ultrasonography (CCUS) ...

Ultrasonographic Assessment During Cardiopulmonary Resuscitation

The US-CAB (Ultrasound, Circulation/Airway/Breathing) protocol integrates several sonographic techniques into a structured assessment of the circulation, airway, and breathing status of a patient during cardiopulmonary resuscitation (CPR) in an advanced life support-compliant manner. US-C provides a subxiphoid view of the heart, to look for potentially reversible causes of disease, such as pericardial effusion, pulmonary embolism, hypovolemia, and acute coronary thrombosis. Sonographic cardiac activity during CPR not only helps differentiate pseudo-pulseless electrical activity (PEA) from true PEA but also represents a higher chance of the return of spontaneous circulation (ROSC) and survival. Evaluation of the inferior vena cava (IVC) shows the fluid status of the patient and indicates the best methods to use for fluid resuscitation. If aortic dissection is suspected, a subxiphoid view of the aorta is suggested for identifying an intimal flap. Once intubation is done, tracheal ultrasound (US-A) at the suprasternal notch helps differentiate endotracheal intubation (one air-mucosal interface with one comet-tail) from esophageal intubation (double tract sign). Immediately following US-A, bilateral lung US (US-B) should be done to confirm proper bilateral ventilation using the lung sliding sign. In addition, US-C can be serially followed to see the dynamic changes in the cardiac chambers and IVC, or any cardiac contraction suggestive of ROSC. US-B can also detect coexisting lung or pleural pathologies without interfering with the performance of CPR. The main concern when implementing this method is maintaining high-quality CPR without delays in chest compressions when performing US-CAB. Rigorous training and continued practice are key to minimize any interruptions during resuscitation.

Here, we present a US-CAB (Ultrasound, Circulation/Airway/Breathing) protocol for use during cardiopulmonary resuscitation (CPR). US-C evaluates the subxiphoid view of the heart and inferior vena cava. After intubation, tracheal US (US-A) and lung US (US-B) help confirm endotracheal intubation and proper ventilation.

The US-CAB (Ultrasound, Circulation/Airway/Breathing) protocol integrates several sonographic techniques into a structured assessment of the circulation, ...

3D Angiography for Venous Compliance Assessment in Sheep

Quantifying Inferior Vena Cava Compliance and Distensibility in an In Vivo Ovine Model Using 3D Angiography

Synthetic vascular grafts overcome some challenges of allografts, autografts, and xenografts but are often more rigid and less compliant than the native vessel into which they are implanted. Compliance matching with the native vessel is emerging as a key property for graft success. The current gold standard for assessing vessel compliance involves the vessel's excision and ex vivo biaxial mechanical testing. We developed an in vivo method to assess venous compliance and distensibility that better reflects natural physiology and takes into consideration the impact of a pressure change caused by flowing blood and by any morphologic changes present. 
This method is designed as a survival procedure, facilitating longitudinal studies while potentially reducing the need for animal use. Our method involves injecting a 20 mL/kg saline bolus into the venous vasculature, followed by the acquisition of pre and post bolus 3D angiograms to observe alterations induced by the bolus, concurrently with intravascular pressure measurements in target regions. We are then able to measure the circumference and the cross-sectional area of the vessel pre and post bolus. 
With these data and the intravascular pressure, we are able to calculate the compliance and distensibility with specific equations. This method was used to compare the inferior vena cava's compliance and distensibility in native unoperated sheep to the conduit of sheep implanted with a long-term expanded polytetrafluorethylene (PTFE) graft. The native vessel was found to be more compliant and distensible than the PTFE graft at all measured locations. We conclude that this method safely provides in vivo measurements of vein compliance and distensibility.

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research

This protocol allows for the in vivo quantification of venous compliance and distensibility using catheterization and 3D angiography as a survival procedure allowing for a variety of potential applications.

Synthetic vascular grafts overcome some challenges of allografts, autografts, and xenografts but are often more rigid and less compliant than the native ...

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Targeted neonatal echocardiography (TnECHO) refers to the use of comprehensive echocardiographic evaluation and physiologic data to obtain accurate, reliable, and real-time information on developmental hemodynamics in sick newborns. The comprehensive assessment is based on a multiparametric approach that overcomes the reliability issues of individual measurements, allows for earlier recognition of cardiovascular compromise and promotes enhanced diagnostic precision and timely management. TnECHO-driven research has led to an enhanced understanding of the mechanisms of illness and the development of predictive models to identify at-risk populations. This information may then be used to formulate a diagnostic impression and provide individualized guidance for the selection of cardiovascular therapies. TnECHO is based on the expert consultative model in which a neonatologist, with advanced training in neonatal hemodynamics, performs comprehensive and standardized TnECHO assessments. The distinction from point of care ultrasonography (POCUS), which provides limited and brief one-time assessments, is important. Neonatal hemodynamics training is a 1-year structured program designed to optimize image acquisition, measurement analysis, and hemodynamic knowledge (physiology, pharmacotherapy) to support cardiovascular decision-making. Neonatologists with hemodynamic expertise are trained to recognize deviations from normal anatomy and appropriately refer cases of possible structural abnormalities. We provide an outline of neonatal hemodynamics training, the standardized TnECHO imaging protocol, and an example of representative echo findings in a hemodynamically significant patent ductus arteriosus.

Presented here is a protocol to perform comprehensive neonatal echocardiography by trained neonatologists in the neonatal intensive care unit. The trained individuals provide longitudinal assessments of heart function, systemic and pulmonary hemodynamics in a consultative role. The manuscript also describes the requirements to become a fully trained neonatal hemodynamics specialist.

Targeted neonatal echocardiography (TnECHO) refers to the use of comprehensive echocardiographic evaluation and physiologic data to obtain accurate, ...

Troubleshooting FoCUS Image Acquisition: Patient Positioning, Transducer Manipulation, and Image Optimization

Focused cardiac ultrasound (FoCUS) is a limited, clinician-performed application of echocardiography to add real-time information to patient care. These bedside exams are problem oriented, rapidly and repeatedly performed, and largely qualitative in nature. Competency in FoCUS includes mastery of the stereotactic and psychomotor skills required for transducer manipulation and image acquisition. Competency also requires the ability to optimize the setup, troubleshoot image acquisition, and understand the sonographic limitations because of complex clinical environments and patient pathology. This article presents concepts for successful, high-quality two-dimensional (B-mode) image acquisition in FoCUS.
Concepts of high-quality image acquisition can be applied to all established sonographic windows of the FoCUS exam: the parasternal long-axis (PLAX), parasternal short-axis (PSAX), apical four chamber (A4C), subcostal fourchamber (SC4C), and the inferior vena cava (IVC). The apical five-chamber (A5C) and subcostal short-axis (SCSA) views are mentioned, but are not discussed in-depth. A pragmatic figure illustrating the movements of the phased array transducer is also provided to serve as a cognitive aid during FoCUS image acquisition.

Here, we present a protocol to allow providers to perform focused cardiac ultrasound (FoCUS) in the clinical environment. We describe methods of transducer manipulation, review common pitfalls of transducer movements, and suggest tips to optimize phased array transducer use.

Focused cardiac ultrasound (FoCUS) is a limited, clinician-performed application of echocardiography to add real-time information to patient care. These ...

Imaging the Abdominal Aorta with Point-of-Care Ultrasound

An Approach to Point-Of-Care Ultrasound Evaluation of the Abdominal Aorta

Disorders of the abdominal aorta, including aneurysms and dissection, have potentially high rates of morbidity and mortality. While computed tomography (CT) is the current gold standard to image the abdominal aorta, the process of obtaining a CT may be time-consuming, requires the use of intravenous contrast dye, and involves exposure to ionizing radiation. Point-of-care Ultrasound (POCUS) can be performed at the bedside and has excellent sensitivity and specificity for the diagnosis of abdominal aortic aneurysm and excellent specificity for the diagnosis of abdominal aortic dissection. Additionally, POCUS is non-invasive, cost-effective, lacks ionizing radiation, requires no intravenous contrast dye, and can be performed without taking the patient from a critical care area. Screening for abdominal aortic aneurysm (AAA) can be done in primary care settings as well. 
This article will review the approach to POCUS of the abdominal aorta to evaluate such critical pathology. In this paper, we will review the sonographic anatomy of the abdominal aorta as well as the choice of the ultrasound probe, description of POCUS image acquisition, and some pearls and pitfalls of using POCUS to aid in the diagnosis of potentially life-threatening abdominal aortic pathology.

Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta

This protocol reviews the steps to image the abdominal aorta with point-of-care ultrasound. We discuss image acquisition, troubleshooting imaging pitfalls and artifacts, and the recognition of life-threatening abdominal aortic pathology.

Disorders of the abdominal aorta, including aneurysms and dissection, have potentially high rates of morbidity and mortality. While computed tomography ...

POCUS Protocol for IVC Assessment in Management of Heart Failure

Workflow and Framework for Collecting and Implementing Point-of-Care Ultrasound Data in the Management of Heart Failure Patients

Management and prevention of acute decompensated heart failure remain highly prevalent and challenging medical conditions. Incorporation of Point-of-Care Ultrasound (POCUS) as an adjunctive tool for assessing volume status and treatment response has shown significant promise. POCUS can be used for imaging internal anatomic structures serially and capturing these images for comparison and measurement over time. This protocol describes a scalable and standardized methodology for the serial assessment of the inferior vena cava (IVC). The methodology includes serial image collection, measurement, and presentation in the electronic medical record. A workflow for POCUS-acquired images of the IVC was created to capture the images and measure the diameter in a discrete data field for direct comparison over time and in response to clinical management. The protocol also includes the assessment of the presence or absence of pleural effusion as discrete data in the standardized workflow. By integrating POCUS into heart failure management, clinicians can improve patient outcomes through more precise and timely adjustments in treatment.

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients

This protocol presents a scalable workflow for the use of point-of-care ultrasound in the management of hospitalized and outpatient heart failure patients.

Management and prevention of acute decompensated heart failure remain highly prevalent and challenging medical conditions. Incorporation of Point-of-Care ...