In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

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05:32 min

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February 16th, 2024

DOI :

10.3791/66026-v

February 16th, 2024

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Wenchao Zhang¹^,², Xue Wei¹^,², Qingliang Wang¹^,², Kai Dai¹^,²^,³, Jing Wang¹^,²^,⁴, Changsheng Liu²^,³^,⁴

¹State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, ²Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology, ³Key Laboratory for Ultrafine Materials of the Ministry of Education, East China University of Science and Technology, ⁴Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology

Summary

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In Vivo Osteo organoid

Therapeutic Hematopoietic Stem Cells

Bioactive Materials

Stem Cell Culture

Disease Treatment

Microenvironment Construction

Recombinant Human Stock Solution

Gelatin Sponge

Implantation Protocol

Muscle Tissue Removal

Histological Analysis

Bioactive Scaffold

Osteo organoids

Chapters in this video

0:00

Introduction

1:21

Fabrication of Bone Morphogenetic Protein‐2 (BMP‐2)‐Loaded Gelatin Scaffold to Harvest Therapeutic Hematopoietic Stem/Progenitor Cells

2:07

Surgical Implantation of Bioactive Scaffolds in Mice to Generate Osteo‐Organoids