مصدر التمويل / رقم البيولوجيا الجزيئية من الصدمة النزفية GM053789

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L., Uchida, T., Kramer, G. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fluid+compartment+in+hemorrhaged+rats+after+hyperosmotic+crystalloid+and+hyperoncotic+crystalloid+resuscitation.">Fluid compartment in hemorrhaged rats after hyperosmotic crystalloid and hyperoncotic crystalloid resuscitation.</a> Am J Physiol. 270, F1-F8 (1996).</li><li>Perel, P., Roberts, I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Colloids+vs+crystalloids+for+fluid+resuscitation+in+critically+ill+patients.">Colloids vs crystalloids for fluid resuscitation in critically ill patients.</a> Cochrane Database System Rev. 4, CD000567-CD000567 (2007).</li></ol>

وكان يشرف على التجارب على الحيوانات والذي يجرى وفقا للمبادئ التوجيهية واللوائح التي وضعتها المؤسسات ورعاية الحيوان واستخدام اللجنة إجراء البحوث ومكتب الالتزام من جامعة بيتسبرغ ، وهي معتمدة بالكامل AALAS / المؤسسة AALAC. وتشمل المصادر الحيوانية جاكسون المختبرات والمعامل تشارلز ريفرز. تخضع جميع الحيوانات واسعة لضمان الصحة من خلال كل بائع ، وكذلك جامعة بيتسبرغ الداخلية برامج رصد الصحة الحيوانية. وتجري هذه البحوث وفقا لمدراء الحكومة الامريكية لاستخدام الحيوانات الفقارية. تم تسجيل البرنامج مع وزارة الزراعة ، وخطاب ضمان مع مكتب الخدمات الصحية العامة لرعاية الحيوان المعملية.

<table border="1" style=";text-align:right;direction:rtl"><tbody><tr><th> صك </th><th> الصانع </th><th> رقم كتالوج </th></tr><tr><td> Dumonts (SS/45 ° زاوية 0.2x0.12mm معلومات سرية ، وطول 13.5cm) </td><td> أدوات العلوم غرامة </td><td> 11203-25 </td></tr><tr><td> مقص جراحي (مستقيم 12cm) </td><td> أدوات العلوم غرامة </td><td> 14068-12 </td></tr><tr><td> المرقأة (المنحني - 12.5cm) </td><td> أدوات العلوم غرامة </td><td> 13009-12 </td></tr><tr><td> Microscissors (ربيع مقص على التوالي ، 8cm) </td><td> أدوات العلوم غرامة </td><td> 15000-00 </td></tr><tr><td> ملقط (0.8mm - تلميح ، منحنية ، 10cm) </td><td> أدوات العلوم غرامة </td><td> 11050-10 </td></tr><tr><td> الدرز بكرة 6-0 </td><td> أدوات العلوم غرامة </td><td> 18020-60 </td></tr><tr><td> الدرز PDSII 4-0 </td><td> بنسلفانيا البيطرية </td><td> ETHZ304H </td></tr><tr><td> الشاش 4X4 </td><td> ويمكن شراؤها من خلال أي مورد عالمي </td><td></td></tr><tr><td> القطن طرف قضيب </td><td> ويمكن شراؤها من خلال أي مورد عالمي </td><td></td></tr><tr><td> 30G إبرة </td><td> ويمكن شراؤها من خلال أي مورد عالمي </td><td></td></tr><tr><td> 23G إبرة </td><td> ويمكن شراؤها من خلال أي مورد عالمي </td><td></td></tr><tr><td> 3cc حقنة </td><td> ويمكن شراؤها من خلال أي مورد عالمي </td><td></td></tr><tr><td> 5cc حقنة </td><td> ويمكن شراؤها من خلال أي مورد عالمي </td><td></td></tr><tr><td> 10cc حقنة </td><td> ويمكن شراؤها من خلال أي مورد عالمي </td><td></td></tr><tr><td> المخروطية أنبوب 50cc ل </td><td> ويمكن شراؤها من خلال أي مورد عالمي </td><td></td></tr><tr><td> 1cc حقنة ث / 25G إبرة </td><td> فيشر العلمية </td><td> 14-826-88 </td></tr><tr><td> البولي ايثيلين أنابيب 100 10 `(PE - 10) </td><td> فيشر العلمية </td><td> 14-170 - 12P </td></tr><tr><td> البولي ايثيلين أنابيب 100 50 `(PE - 50) </td><td> فيشر العلمية </td><td> 14-170 - 12B </td></tr><tr><td> 3 الطريقة محبس </td><td> فيشر العلمية </td><td> NC9779127 </td></tr><tr><td> لوحة زرقاء الجراحية </td><td> فيشر العلمية </td><td> 50-7105 </td></tr><tr><td> الضمادات المعقمة الميدانية </td><td> فيشر العلمية </td><td> NC9517505 </td></tr><tr><td> شريط القوائم 1 &quot; </td><td> الشركات اكسبرس </td><td> MMM26001 </td></tr><tr><td> مستقيم الجرار الجانب الفم واسعة (كما تستخدم غطاء للمخروط الأنف) </td><td> VWR </td><td> 159000-058 </td></tr><tr><td> علبة من الصلب المقاوم للصدأ 8 &quot;× 11&quot; </td><td> VWR </td><td> 62687-049 </td></tr><tr><td> الذكور الذكور leur قفل الطريق 3 </td><td> VWR </td><td> 20068-909 </td></tr><tr><td> التعقيم الحقيبة 3 &quot;X8&quot; </td><td> VWR </td><td> 24008 </td></tr><tr><td> التعقيم الحقيبة 5 &quot;X10&quot; </td><td> VWR </td><td> 24010 </td></tr><tr><td> M650 المجهر البرية ث / ازدهار الوقوف </td><td> لايكا </td><td></td></tr><tr><td> ايكا IC D كاميرا رقمية / الصورة الحية </td><td> لايكا </td><td></td></tr><tr><td> DIGI المتوسطي BPA - 400 محلل وتكامل الأنظمة </td><td> الجزئي المتوسطي </td><td> SYS - 400 </td></tr><tr><td> TXD - 310 (DIGI - محول ميد) </td><td> الجزئي المتوسطي </td><td> TXD - 300 </td></tr><tr><td> الكمبيوتر </td><td> ديل </td><td></td></tr><tr><td> حبة تعقيم الأدوات الساخنة </td><td> VWR </td><td> 18000-45 </td></tr><tr><td> اوستر A5 كليبرز دبليو حجم 40 النصل </td><td> VWR </td><td> 10749-020 </td></tr><tr><td> تعميم heatinز سادة 18x26 </td><td> جامعة هارفارد </td><td> py872 - 5272 </td></tr><tr><td> مقياس الحرارة المستقيمي </td><td> كينت العلمية </td><td> RET - 3 </td></tr></tbody></table><table border="1" style=";text-align:right;direction:rtl"><tbody><tr><th> الكاشف </th><th> تركيز </th><th> الصانع </th><th> رقم كتالوج </th></tr><tr><td> بنتوباربيتال الصوديوم (Nembutol الحل الصوديوم) </td><td> 70mg/kg </td><td> تصفيق </td><td></td></tr><tr><td> البوبرينورفين حمض الهيدروكلوريك </td><td> 0.1mg/kg </td><td> بيدفورد مختبرات </td><td></td></tr><tr><td> Lactated قارعو الأجراس حقيبة حقن 250CC الرابع </td><td> باكستر </td><td></td><td></td></tr><tr><td> Aerrane (Isoflurane) </td><td> 99.9 ٪ </td><td> NLS صحة الحيوان </td><td> 105996 </td></tr><tr><td> هيبارين الصوديوم </td><td> 1000U </td><td> Abraxis </td><td></td></tr><tr><td> جراثيم كلوريد الصوديوم </td><td> 0.9 ٪ </td><td> هوسبيرا </td><td></td></tr><tr><td> الكحول الإيثيلي </td><td> 70 ٪ </td><td> الصيدلانية AAPER </td><td></td></tr><tr><td> Triadine البوفيدون (Betadine) </td><td></td><td> المستهلكات ثالوث </td><td></td></tr></tbody></table>

fixed volume or fixed pressure: a murine model of hemorrhagic shock

فمن المعروف أن فقدان الدم الحاد والإصابات يمكن أن تؤدي إلى سلسلة من الأحداث الضارة الناجمة غالبا ما يشير الى وفيات في 1 ، 2 ، 3 ، 4 ، 5 يشير الى هذه الأحداث يمكن أيضا أن تؤدي إلى تعفن الدم و / أو ضعف الجهاز متعددة (MOD ) 6 ، 7 ، 8 ، 9 ومن ثم الحاسمة للتحقيق في أسباب وظيفة المناعة قمعها وضارة شلالات إشارات من أجل تطوير طرق أكثر فعالية لمساعدة المرضى الذين يعانون من الإصابات. النزفية 10 هذا ضغط ثابت الصدمة (HS) الداخلي ، على الرغم من صعوبة من الناحية الفنية ، هو مصدر ممتاز للتحقيق في هذه الظروف الفسيولوجية المرضية. 11 ، 12 ، 13 السلف في تقييم النظم البيولوجية ، أي نظم علم الأحياء مكنت المجتمع العلمي إلى زيادة فهم شبكات فيزيولوجية معقدة وأنماط الاتصالات الخلوية (14). وقد أثبتت صدمة نزفية ليكون أداة حيوية لكشف هذه الأنماط الاتصالات الخلوية من حيث صلتها الوظيفة المناعية 15 ، يمكن أن تتقن 16 ، 17 ، 18 هذا الإجراء! ويمكن أيضا أن تستخدم هذا الإجراء من حيث حجم التجارة إما ثابتة أو ثابتة نهج الضغط. نحن تكييف هذه التقنية في النموذج الفأري لتعزيز البحوث في وظيفة المناعة الفطرية والتكيف 19 ، 20 ، 21 ونظرا لصغر حجمها HS في الفئران تحديات فريدة من نوعها. ولكن نظرا إلى سلالات الفأر المتاحة كثيرة ، وهذا النوع يمثل موردا لا مثيل لها لدراسة ردود الفعل البيولوجية. طراز HS هو نموذج مهم لدراسة أنماط الاتصالات الخلوية وردود أنظمة مثل أنظمة الوسيط الهرمونية والتهابات ، وإشارات الخطر ، ورطب أي upregulation PAMP لأنها تثير ردود المتميزة التي تختلف عن غيرها من أشكال الصدمة. 22 ، 23 (24 عاما) قد قدمت 25 وتطوير سلالات الفئران المعدلة وراثيا وتحريض وكلاء بيولوجي لتثبيط إشارات محددة فرصا قيمة لتوضيح مزيد من فهمنا للصعودا ونزولا تنظيم نقل الإشارة بعد فقدان الدم الشديد ، والصدمة HS أي 26 و 27 ، 28 ، 29 ، 30. هناك طرق عديدة الانعاش (R) بالتعاون مع والصدمة HS 31 ، يستخدم 32 و 33 و 34 ألف الإنعاش حجم ثابت طريقة حل الجرس lactated فقط (من اليسار) ، أي ما يعادل ثلاثة أضعاف حجم سفك الدم ، في هذا النموذج لدراسة الآليات الذاتية مثل إصابة الجهاز البعيد والالتهابات الجهازية. ثبت 35 ، 36 ، 38 هذا الأسلوب من الإنعاش لتكون فعالة في تقييم آثار الصدمات النفسية وHS 38 و 39.

Watch this Scientific Journal Video about Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock at JoVE.com

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

لقد كان النموذج الصدمة النزفية مورد موثوق بها وقابلة للتكرار تسهيل تحديد وفهم الإشارات شلالات المرتبطة الالتهاب والضرر نهاية الجهاز بعد الصدمة. توفر هذه المقالة وصفا خطوة بخطوة من الجوانب الجراحية والميكانيكية المرتبطة الداخلي الصدمة النزفية التجريبية في الفئران.

حجم ثابت أو ضغط ثابت : نموذج الفئران من الصدمة النزفية

It is common knowledge that severe blood loss and traumatic injury can lead to a cascade of detrimental signaling events often resulting in mortality. 1, ...

fixed-volume-or-fixed-pressure-a-murine-model-of-hemorrhagic-shock

Research

JoVE Journal

Medicine

24.7K Views.  University of Pittsburgh. لقد كان النموذج الصدمة النزفية مورد موثوق بها وقابلة للتكرار تسهيل تحديد وفهم الإشارات شلالات المرتبطة الالتهاب والضرر نهاية الجهاز بعد الصدمة. توفر هذه المقالة وصفا خطوة بخطوة من الجوانب الجراحية والميكانيكية المرتبطة الداخلي الصدمة النزفية التجريبية في ال?...

Video: Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

A Murine Model of Subarachnoid Hemorrhage

In this video publication a standardized mouse model of subarachnoid hemorrhage (SAH) is presented. Bleeding is induced by endovascular Circle of Willis perforation (CWp) and proven by intracranial pressure (ICP) monitoring. Thereby a homogenous blood distribution in subarachnoid spaces surrounding the arterial circulation and cerebellar fissures is achieved. Animal physiology is maintained by intubation, mechanical ventilation, and continuous on-line monitoring of various physiological and cardiovascular parameters: body temperature, systemic blood pressure, heart rate, and hemoglobin saturation. Thereby the cerebral perfusion pressure can be tightly monitored resulting in a less variable volume of extravasated blood. This allows a better standardization of endovascular filament perforation in mice and makes the whole model highly reproducible. Thus it is readily available for pharmacological and pathophysiological studies in wild type and genetically altered mice.

A standardized mouse model of subarachnoid hemorrhage by intraluminal Circle of Willis perforation is described. Vessel perforation and subarachnoid bleeding are monitored by intracranial pressure monitoring. In addition various vital parameters are recorded and controlled to maintain physiologic conditions.

A نموذج من الفئران تحت العنكبوتية نزف

In this video publication a standardized mouse model of subarachnoid  hemorrhage (SAH) is presented. Bleeding is induced by endovascular Circle of  Willis ...

Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring

Uncontrolled hemorrhage is an important cause of preventable deaths among trauma patients. We have developed a murine model of uncontrolled hemorrhage via a liver laceration that results in consistent blood loss, hemodynamic alterations, and survival.
Mice undergo a standardized resection of the left-middle lobe of the liver. They are allowed to bleed without mechanical intervention. Hemostatic agents can be administered as pre-treatment or rescue therapy depending on the interest of the investigator. During the time of hemorrhage, real-time hemodynamic monitoring via a left femoral arterial line is performed. Mice are then sacrificed, blood loss is quantified, blood is collected for further analysis, and organs are harvested for analysis of injury. Experimental design is described to allow for simultaneous testing of multiple animals.
Liver hemorrhage as a model of uncontrolled hemorrhage exists in the literature, primarily in rat and porcine models. Some of these models utilize hemodynamic monitoring or quantify blood loss but lack consistency. The present model incorporates quantification of blood loss, real-time hemodynamic monitoring in a murine model that offers the advantage of using transgenic lines and a high-throughput mechanism to further investigate the pathophysiologic mechanisms in uncontrolled hemorrhage.

Uncontrolled hemorrhage, an important cause of mortality among trauma patients, can be modeled using a standard liver laceration in a murine model. This model results in consistent blood loss, survival, and allows for testing hemostatic agents. This article provides the step-by-step process to perform this valuable model.

صدمة النزفية غير المنضبط نمذجة عبر الكبد تهتز في الفئران مع رصد الدورة الدموية في الوقت الحقيقي

Uncontrolled hemorrhage is an important cause of preventable deaths among trauma patients. We have developed a murine model of uncontrolled hemorrhage via ...

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) is a subtype of hemorrhagic stroke. Cerebral vasospasm that occurs in the aftermath of the bleeding is an important factor determining patient outcome and is therefore frequently taken as a study endpoint. However, in small animal studies on SAH, quantification of cerebral vasospasm is a major challenge. Here, an ex vivo method is presented that allows quantification of volumes of entire vessel segments, which can be used as an objective measure to quantify cerebral vasospasm. In a first step, endovascular casting of the cerebral vasculature is performed using a radiopaque casting agent. Then, cross-sectional imaging data are acquired by micro computed tomography. The final step involves 3-dimensional reconstruction of the virtual vascular tree, followed by an algorithm to calculate center lines and volumes of the selected vessel segments. The method resulted in a highly accurate virtual reconstruction of the cerebrovascular tree shown by a diameter-based comparison of anatomical samples with their virtual reconstructions. Compared with vessel diameters alone, the vessel volumes highlight the differences between vasospastic and non-vasospastic vessels shown in a series of SAH and sham-operated mice.

The goal of this article is to present a method that allows a 3-dimensional reconstruction of the cerebrovascular tree in mice after micro computed tomography and determination of volumes of entire vessel segments that can be used to quantify cerebral vasospasm in murine models of subarachnoid hemorrhage.

أسلوب حجمي للتحديد الكمي للمخ بالتشنج في نموذج موريني نزيف تحت العنكبوتية

Subarachnoid hemorrhage (SAH) is a subtype of hemorrhagic stroke. Cerebral vasospasm that occurs in the aftermath of the bleeding is an important factor ...

Neuroscience

Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice

Acute myocardial infarction can lead to acute heart failure and cardiogenic shock. The evaluation of hemodynamics is critical for the evaluation of any potential therapeutic approach directed against acute left ventricular (LV) dysfunction. Current imaging modalities (e.g., echocardiography and magnetic resonance imaging) have several limitations since data on LV pressure cannot directly be measured. LV catheterization in mice undergoing coronary artery occlusion could serve as a novel method for a real-time evaluation of LV function.
At the beginning of the procedure, mice were anesthetized followed by endotracheal intubation. For LV catheterization, the right carotid artery was exposed via middle-neck incision. The catheter was introduced and placed into the LV cavity. Left thoracotomy was conducted and the left main coronary artery (LCA) was ligated. To induce reperfusion, the suture was released after 45 min. Pressure-volume data was recorded at all times.
Ligation of the LCA caused a decrease in LV systolic function as evidenced by a 30% reduction in stroke volume, LV ejection fraction (EF), and cardiac output. Maximum dP/dt as a parameter for LV contractility was also significantly reduced and diastolic function was severely impaired (minimum dP/dt -40%). Reperfusion over a period of 20 min did not lead to a complete recovery of LV function.
Real-time pressure-volume analysis served as a valid procedure for monitoring cardiac function during acute myocardial infarction in mice. Maintaining stable anesthesia and a standardized surgical approach was crucial to ensure valid results. As the early phase of acute myocardial infarction is critical for morbidity and mortality, the delineated method could be beneficial for preclinical evaluation of new strategies for cardioprotection.

Acute myocardial infarction in mice induces acute but incompletely characterized changes in left ventricular (LV) function. LV catheterization in mice undergoing coronary artery occlusion serves as a novel method for a real-time evaluation of LV function.

تحليل حجم الضغط في الوقت الحقيقي من احتشاء عضلة القلب الحاد في الفئران

Acute myocardial infarction can lead to acute heart failure and cardiogenic shock. The evaluation of hemodynamics is critical for the evaluation of any ...

Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine

Hemorrhage remains the leading cause of preventable deaths in trauma. Endovascular management of non-compressible torso hemorrhage has been at the forefront of trauma care in recent years. Since complete aortic occlusion presents serious concerns, the concept of partial aortic occlusion has gained a growing attention. Here, we present a large animal model of hemorrhagic shock to investigate the effects of a novel partial aortic balloon occlusion catheter and compare it with a catheter that works on the principles of complete aortic occlusion. Swine are anesthetized and instrumented in order to conduct controlled fixed-volume hemorrhage, and hemodynamic and physiological parameters are monitored. Following hemorrhage, aortic balloon occlusion catheters are inserted and inflated in the supraceliac aorta for 60 min, during which the animals receive whole-blood resuscitation as 20% of the total blood volume (TBV). Following balloon deflation, the animals are monitored in a critical care setting for 4 h, during which they receive fluid resuscitation and vasopressors as needed. The partial aortic balloon occlusion demonstrated improved distal mean arterial pressures (MAPs) during the balloon inflation, decreased markers of ischemia, and decreased fluid resuscitation and vasopressor use. As swine physiology and homeostatic responses following hemorrhage have been well-documented and are like those in humans, a swine hemorrhagic shock model can be used to test various treatment strategies. In addition to treating hemorrhage, aortic balloon occlusion catheters have become popular for their role in cardiac arrest, cardiac and vascular surgery, and other high-risk elective surgical procedures.

Here, we present a protocol demonstrating a hemorrhagic shock model in swine that uses aortic occlusion as a bridge to definitive care in trauma. This model has application in testing a wide range of surgical and pharmacological therapeutic strategies.

انسداد الابهري كاملة وجزئية لعلاج الصدمة النزفية في الخنازير

Hemorrhage remains the leading cause of preventable deaths in trauma. Endovascular management of non-compressible torso hemorrhage has been at the ...

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Hemorrhagic shock ranks among the main reasons for severe injury-related death. The loss of circulatory volume and oxygen carriers can lead to an insufficient oxygen supply and irreversible organ failure. The brain exerts only limited compensation capacities and is particularly at high risk of severe hypoxic damage.This article demonstrates the reproducible induction of life-threatening hemorrhagic shock in a porcine model by means of calculated blood withdrawal. We titrate shock induction guided by near-infrared spectroscopy&#160;and extended hemodynamic monitoring to display systemic circulatory failure, as well as cerebral microcirculatory oxygen depletion. In comparison to similar models that primarily focus on predefined removal volumes for shock induction, this approach highlights a titration by means of the resulting failure of macro- and microcirculation.

Hemorrhagic shock is a severe complication in seriously injured patients, which leads to life-threatening oxygen undersupply. We present a standardized method to induce hemorrhagic shock via blood withdrawal in pigs that is guided by hemodynamics and microcirculatory cerebral oxygenation.

الحث الموحد للصدمات النزفية مسترشداً بالقياس الأكسجة الدماغية والرصد الهيمودينامي الموسع في الخنازير

Hemorrhagic shock ranks among the main reasons for severe injury-related death. The loss of circulatory volume and oxygen carriers can lead to an ...

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Survivors of intraventricular hemorrhage are often left with significant long-term memory impairment; thus, research utilizing intraventricular hemorrhage animal models is essential. In this study, we sought out ways to measure intracranial pressure, mean arterial pressure, and cerebral perfusion pressure during nontraumatic intraventricular hemorrhage in rats. The experimental design included three Sprague Dawley groups: sham, standard 200 &#181;l intraventricular hemorrhage, and vehicle control groups. By introducing an intraparenchymal fiberoptic pressure sensor, precise intracranial pressure measurements were obtained in all groups. Cerebral perfusion pressures were calculated with the knowledge of intracranial pressure and mean arterial pressure values. As expected, the intraventricular hemorrhage and vehicle control groups both experienced a rise in the intracranial pressure and subsequent decline in cerebral perfusion pressure during intraventricular injection of autologous blood and artificial cerebrospinal fluid, respectively. The addition of an intraparenchymal fiberoptic pressure sensor is beneficial in monitoring precise intracranial pressure changes.

Monitoring intracranial pressure in rodent&#160;models of nontraumatic intraventricular hemorrhage is not common in the current literature. Herein, we demonstrate a technique for measuring intracranial pressure, mean arterial pressure, and cerebral perfusion pressure during intraventricular hemorrhage in a rat&#160;animal model.

مراقبة الضغط داخل الجمجمة في نموذج القوارض النزفية داخل البطينات غير الرضحية

Survivors of intraventricular hemorrhage are often left with significant long-term memory impairment; thus, research utilizing intraventricular hemorrhage ...

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Hemorrhagic shock is a leading cause of morbidity and mortality in pediatric patients. Interpretation of the clinical indicators validated in adults to guide resuscitation and comparison between different therapies is difficult in children due to the inherent heterogeneity of this population. As a result, compared to adults, appropriate management of pediatric hemorrhagic shock is still not well established. In addition, the scarcity of pediatric patients with hemorrhagic shock precludes the development of clinically relevant studies. For this reason, an experimental pediatric animal model is necessary to study the effects of hemorrhage in children as well as their response to different therapies. We present an infant animal model of volume-controlled hemorrhagic shock in anesthetized young pigs. Hemorrhage is induced by withdrawing a previously calculated blood volume, and the pig is subsequently monitored and resuscitated with different therapies. Here, we describe a precise and highly reproducible model of hemorrhagic shock in immature swine. The model yields hemodynamic data that characterizes compensatory mechanisms that are activated in response to severe hemorrhage.

This article aims to provide researchers with a detailed and accessible guide to set up an infant porcine model of hemorrhagic shock.

وصف نموذج رضيع الخنازير للصدمة النزفية التي يتم التحكم فيها بالحجم

Hemorrhagic shock is a leading cause of morbidity and mortality in pediatric patients. Interpretation of the clinical indicators validated in adults to ...

قنية الأوعية الدموية مع تحريض الصدمة النزفية في الفئران

Developing a Clinically Relevant Hemorrhagic Shock Model in Rats

Over the recent decades, the development of animal models allowed us to better understand various pathologies and identify new treatments. Hemorrhagic shock, i.e., organ failure due to rapid loss of a large volume of blood, is associated with a highly complex pathophysiology involving several pathways. Numerous existing animal models of hemorrhagic shock strive to replicate what happens in humans, but these models have limits in terms of clinical relevance, reproducibility, or standardization. The aim of this study was to refine these models to develop a new model of hemorrhagic shock. Briefly, hemorrhagic shock was induced in male Wistar Han rats (11-13 weeks old) by a controlled exsanguination responsible for a drop in the mean arterial pressure. The next phase of 75 min was to maintain a low mean arterial blood pressure, between 32 mmHg and 38 mmHg, to trigger the pathophysiological pathways of hemorrhagic shock. The final phase of the protocol mimicked patient care with an administration of intravenous fluids, Ringer Lactate solution, to elevate the blood pressure. Lactate and behavioral scores were assessed 16 h after the protocol started, while hemodynamics parameters and plasmatic markers were evaluated 24 h after injury. Twenty-four hours post-hemorrhagic shock induction, the mean arterial and diastolic blood pressure were decreased in the hemorrhagic shock group (p&#160;&#60; 0.05). Heart rate and systolic blood pressure remained unchanged. All organ damage markers were increased with the hemorrhagic shock (p &#60; 0.05). The lactatemia and behavioral scores were increased compared to the sham group (p &#60; 0.05). In conclusion, we demonstrated that the protocol described here is a relevant model of hemorrhagic shock that can be used in subsequent studies, particularly to evaluate the therapeutic potential of new molecules.

تسليط الضوء على المؤلف: تطوير استراتيجيات علاجية مبتكرة لأبحاث الصدمة النزفية

Hemorrhagic shock kills 1.9 million people worldwide every year. Small animals are frequently used as hemorrhagic shock models but are associated with issues of standardization, reproducibility, and clinical significance, thus limiting their relevance. This article describes developing a new clinically relevant hemorrhagic shock model in rats.

تطوير نموذج صدمة نزفية ذات صلة سريريا في الفئران

Over the recent decades, the development of animal models allowed us to better understand various pathologies and identify new treatments. Hemorrhagic ...

حجم ثابت أو ضغط ثابت : نموذج الفئران من الصدمة النزفية

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A نموذج من الفئران تحت العنكبوتية نزف

صدمة النزفية غير المنضبط نمذجة عبر الكبد تهتز في الفئران مع رصد الدورة الدموية في الوقت الحقيقي

أسلوب حجمي للتحديد الكمي للمخ بالتشنج في نموذج موريني نزيف تحت العنكبوتية

تحليل حجم الضغط في الوقت الحقيقي من احتشاء عضلة القلب الحاد في الفئران

انسداد الابهري كاملة وجزئية لعلاج الصدمة النزفية في الخنازير

الحث الموحد للصدمات النزفية مسترشداً بالقياس الأكسجة الدماغية والرصد الهيمودينامي الموسع في الخنازير

مراقبة الضغط داخل الجمجمة في نموذج القوارض النزفية داخل البطينات غير الرضحية

وصف نموذج رضيع الخنازير للصدمة النزفية التي يتم التحكم فيها بالحجم

تطوير نموذج صدمة نزفية ذات صلة سريريا في الفئران

تطوير نموذج صدمة نزفية ذات صلة سريريا في الفئران