8226 LUC Engraftment and In Vivo Bioluminescence Monitoring
1:58
Targeted Therapy and Tumor Metabolism Monitoring
3:49
Results: Representative Multimodal Multiple Myeloma Bone Marrow Xenograft Monitoring
4:53
Conclusion
副本
This method can be used to answer key questions about the role of the bone marrow micro-environment and the survival of engrafted myeloma tumors. The main advantage of this procedure is that it can be applied to longitudinal anti-drug studies and
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Here we use bioluminescent, X-ray, and positron-emission tomography/computed tomography imaging to study how inhibiting mTOR activity impacts bone marrow-engrafted myeloma tumors in a xenograft model. This allows for physiologically relevant, non-invasive, and multimodal analyses of the anti-myeloma effect of therapies targeting bone marrow-engrafted myeloma tumors in vivo.