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JoVE Journal

Cancer Research

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

6.6K Views

05:32 min

January 7th, 2019

January 7th, 2019

6,632 Views

0:04

Title

0:34

8226 LUC Engraftment and In Vivo Bioluminescence Monitoring

1:58

Targeted Therapy and Tumor Metabolism Monitoring

3:49

Results: Representative Multimodal Multiple Myeloma Bone Marrow Xenograft Monitoring

4:53

Conclusion

Transcription

This method can be used to answer key questions about the role of the bone marrow micro-environment and the survival of engrafted myeloma tumors. The main advantage of this procedure is that it can be applied to longitudinal anti-drug studies and

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Here we use bioluminescent, X-ray, and positron-emission tomography/computed tomography imaging to study how inhibiting mTOR activity impacts bone marrow-engrafted myeloma tumors in a xenograft model. This allows for physiologically relevant, non-invasive, and multimodal analyses of the anti-myeloma effect of therapies targeting bone marrow-engrafted myeloma tumors in vivo.

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