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In This Article

  • Summary
  • Abstract
  • Introduction
  • Protocol
  • Representative Results
  • Discussion
  • Acknowledgements
  • Materials
  • References
  • Reprints and Permissions

Summary

Varicocele relies heavily on angiographic diagnostic techniques for disease-related examination and assessment. In order to diagnose varicocele better, we combined supine and standing positions for varicocele imaging, and contrast-enhanced ultrasound is used for patients with inconspicuous reflux. This approach facilitates the early detection, diagnosis, and treatment of varicocele.

Abstract

Varicocele, one of the main diseases affecting male reproductive health, relies heavily on angiographic diagnostic techniques for disease-related examination and assessment. Traditional varicocele angiography often employs a supine position to facilitate the relaxation of the groin area muscles, the insertion of the angiography catheter, and imaging. However, the supine position may cause blood reflux, thus underestimating the clinical incidence of varicocele, particularly resulting in missed diagnoses of right-sided or bilateral varicoceles. To address this issue, this study proposes the combined use of supine and standing positions for varicocele imaging. The standing position increases lower abdominal pressure, making the degree of varicosity more prominent in the images. Compared to the sole use of the supine position, the method employed in this study effectively reduces the misdiagnosis rate of right-sided or bilateral varicoceles. This approach aims to facilitate the early detection, diagnosis, and treatment of varicocele, effectively reducing the potential threat of the disease to male reproductive health. It also helps improve the accuracy of disease assessment, providing more references for selecting subsequent treatment plans.

Introduction

Globally, infertility has gradually emerged as an issue of pressing concern for clinicians and researchers, with related disorders receiving significant attention. Among these, varicocele (VC) is considered one of the primary causes of male infertility, especially with an incidence rate reaching up to 80% in the secondary infertile population1. Accurate and timely diagnosis for such diseases is pivotal, as it directly dictates the subsequent choice of treatment and its efficacy.

The conventional diagnostic method for varicocele primarily relies on clinical manifestations and physical examinations2

Protocol

This study received approval from the Shanghai Hospital of Planned Parenthood Research. The diagnostic criteria, surgical indications, and contraindications are in line with the expert consensus of the "Guidelines for Andrological Diagnostics and Treatment," the "Chinese Andrology Society," and the "European Association of Urology Sexual and Reproductive Health Guidelines." Patients with female partners suffering from diseases affecting fertility were excluded from this study. Informed consent was.......

Representative Results

From June 2022 to June 2023, our institution conducted a total of 2,789 testicular vein ultrasound examinations. Among them, the positive detection rate for varicocele was 84.51%. Specifically, 24.35% of the patients had unilateral (left) varicocele, 2.34% had unilateral (right) varicocele, and 73.31% had bilateral varicocele. Notably, in the supine ultrasound examination (Figure 1), approximately 48.45% of the patients did not show varicose veins on the right side of the spermatic cord (

Discussion

With the intensification of research in the realm of male reproductive health in recent years, varicocele has been recognized as one of the primary factors affecting male fertility. Although its clinical manifestations are diverse, accurate and effective diagnosis remains a pivotal step in determining therapeutic outcomes. Physical examination (PE) is extremely important in screening for varicocele; a worm-like varicose vein at the base of the scrotum can be seen in severe varicocele patients, and for mild to moderate va.......

Acknowledgements

None.

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Materials

NameCompanyCatalog NumberComments
Dianerkang Iodophor Skin DisinfectantShanghai Likang Disinfectant HI-Tech Co,Lid31005102For skin disinfection and the effective iodine content is from 4.5g/L~5.5g/L
Disposable dressing forcepsJiaxing Zhongxin Medical Instrument Co., LtdMLD-01Holding disinfectant cotton balls for disinfection
Physiological salineShanghai Kindly Medical Instruments Co., Ltd2452161324Used for injecting contrast agents
Shallow probe (high frequency)General Electric CompanyVoluson E6Devices for transmitting and receiving ultrasonic waves
Sulfur hexafluoride microbubbles for injectionBRACCO INTERNATIONAL BVSonoVueImprove the ultrasound echo rate of blood, thereby improving the contrast between blood and surrounding tissues
Ultrasonic coupling agentShanghai Junkang Medical Equipment Co., LtdDS-1Eliminate air gaps between the probe and the detected object, improve the transmission efficiency of ultrasound
Ultrasound diagnostic equipmentGeneral Electric CompanyVoluson E6Process and display the signal received from the probe
Vein Detained NeedleShanghai Kindly Medical Instruments Co., Ltd60017202Indwelling venous channels to reduce drug leakage and save time

References

  1. Alsaikhan, B., Alrabeeah, K., Delouya, G., Zini, A. Epidemiology of varicocele. Asian J Androl. 18 (2), 179-181 (2016).
  2. Chiba, K., Ramasamy, R., Lamb, D. J., Lipshultz, L. I. The varicocele: Diagnostic dilemmas, therapeutic challenges and fut....

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