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Chapitre 7

Réparation de l'ADN et recombinaison

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Aperçu de la réparation de l’ADN

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a ...

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Réparation par excision de base

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and ...

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Réparation par excision de base : voie de synthèse longue

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this ...

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Réparation par excision de nucléotides

Overview Exposure to mutagens can damage DNA and result in bulky lesions that distort the double-helix structure or impede proper transcription. Damaged ...

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ADN polymérases translésionnelles

Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide ...

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Réparer les cassures double brin

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the ...

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L’ADN endommagé peut bloquer le cycle cellulaire

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages ...

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Recombinaison homologue

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of ...

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Redémarrage de la fourche de réplication bloquée

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the ...

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Conversion génique

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the ...

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Aperçu de la transposition et de la recombinaison

Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in ...

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Transposons à ADN

DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. ...

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Rétrovirus

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when ...

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Rétro-transposons à LTR

LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in ...

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Rétro-transposons non-LTR

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and ...

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Recombinaison site-spécifique et variation de phase

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic ...