Chapter 7
DNA 복구/회복과 재조합
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DNA 복구/회복 개요
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a ...
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염기 절제 복구
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and ...
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긴 패치 염기 절제 복구
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this ...
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뉴클레오타이드 절제 복구
Overview
Exposure to mutagens can damage DNA and result in bulky lesions that distort the double-helix structure or impede proper transcription. Damaged ...
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손상통과 DNA 중합효소
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide ...
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두 가닥 절단 복구
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the ...
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DNA 손상에 의한 세포 주기 중단
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages ...
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상동재조합
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of ...
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멈춘 복제 분기점의 재시작
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the ...
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유전자 전환
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the ...
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전위와 재조합 개요
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in ...
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DNA 한정 트랜스포존
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. ...
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레트로바이러스
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when ...
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LTR 레트로트랜스포존
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in ...
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비LTR 레트로트랜스포존
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and ...
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보존적 부위 특이적 재조합과 상변이
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic ...
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