June 3rd, 2020
•This protocol describes the induction of pulmonary hypertension (PH) in mice based on the exposure to hypoxia and the injection of a VEGF receptor antagonist. The animals develop PH and right ventricular (RV) hypertrophy 3 weeks after the initiation of the protocol. The functional and morphometrical characterization of the model is also presented.
Vidéos Connexes
Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets Video (Video) | JoVE
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet Video (Video) | JoVE
Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension Video (Video) | JoVE
A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice Video (Video) | JoVE
Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model Video (Video) | JoVE
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension Video (Video) | JoVE
Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension Video (Video) | JoVE
Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography Video (Video) | JoVE
Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat Video (Video) | JoVE
The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats Video (Video) | JoVE