Total, Calcified, and Uncalcified Cartilage Area Measurements
2:47
Chondrocyte Number and Phenotype Evaluation
3:17
Tibial Articular Surface Perimeter Measurement
3:47
Subchondral Bone and Marrow Space Area Measurement
4:30
Anterior and Posterior Osteophyte Area and Synovial Thickness Measurement
5:21
Results: Representative Histomorphometric Osteoarthritis (OA) Evaluation in Destabilization of the Medial Meniscus (DMM) and Sham Mice
7:06
Conclusion
Transcription
Our protocol addresses an unmet need for a robust and reproducible method for quantitative analysis of joint changes in osteoarthritis development and progression. Our technique outlines specific and reproducible parameters for the quantitative an
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The current protocol establishes a rigorous and reproducible method for quantification of morphological joint changes that accompany osteoarthritis. Application of this protocol can be valuable in monitoring disease progression and evaluating therapeutic interventions in osteoarthritis.