Results: Effect of Magnetic Force on DNA Constructs
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Conclusion
Transcription
Biomolecules undergo small and rapid structural changes often in response to force. High resolution magnetic tweezers can explore these dynamics under physiologically relevant forces. As the method makes nanoscale measurements with millisecond pre
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Here, we describe a high-speed magnetic tweezer setup that performs nanomechanical measurements on force-sensitive biomolecules at the maximum rate of 1.2 kHz. We introduce its application to DNA hairpins and SNARE complexes as model systems, but it will be also applicable to other molecules involved in mechanobiological events.