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Dual-Dye Optical Mapping of Hearts from RyR2^R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

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09:36 min

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December 22nd, 2023

DOI :

10.3791/65082-v

December 22nd, 2023

•

936 Views

Yangpeng Li*¹^,², Jun Yang*¹, Rui Zhang¹, Tangting Chen¹, Shiyu Zhang¹, Yuqing Zheng¹, Qiang Wen³, Tao Li¹, Xiaoqiu Tan¹^,², Ming Lei¹^,⁴, Xianhong Ou¹

¹Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, ²Department of Cardiology, the Affiliated Hospital of Southwest Medical University, ³Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, ⁴Department of Pharmacology, University of Oxford

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要約

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Optical Mapping

RyR2R2474S Knock in Mice

Catecholaminergic Polymorphic Ventricular Tachycardia

Membrane Potential

Intracellular Calcium

Langendorff Perfusion

Excitation contraction Uncoupling

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Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Dual-Dye Optical Mapping of Hearts from RyR2^R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia