Name: electroactive polymer nanoparticles exhibiting photothermal properties
Uploaded: 2016-01-08T14:00:01.000+00:00
Duration: 10 min 16 s
Description: Watch this Scientific Journal Video about Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties at JoVE.com

이 작품은, 텍사스 신흥 기술 기금 (TB의 시작), 텍사스 주립 대학 연​​구 증진 프로그램, 텍사스 주립 대학 박사 연구 활동 (TC에), 재료의 연구 및 교육에 대한 NSF 파트너십 (프렘에 의해 부분적으로 투자되었다 DMR-1205670), 건강의 웰치 재단 (AI-0045) 및 국립 연구소 (R01CA032132).

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The authors have nothing to disclose.

본 연구에서는 전기 활성 고분자 된 NP는 암 치료에 대한 잠재적 인 PTT 에이전트로 합성되었다. NP에의 제조는 에멀젼 중합 한 후 모노머의 합성을 시작으로 설명한다. 이러한 EDOT 및 피롤 같은 전기 활성 고분자를 이용한 된 NP의 제조 이전에 설명되었지만,이 논문은 중합 된 NP의 제조는, 고유의 확장 공액 단량체로 시작하는이 방법은 더 크고 복잡한 단량체로 확장 될 수 있음을 보여주는 설명한다...

전기 활성 중합체는 전계의 존재 하에서 이들 특성 (색, 전도도, 반응성, 볼륨, 등)을 변경. 빠른 스위칭 시간, 조정 기능, 내구성 및 전기 활성 고분자의 경량 특성을 대체 에너지, 센서, electrochromics, 생물 의학 장치를 포함하여 많은 제안 응용 프로그램을 주도하고있다. 전기 활성 고분자는 유연성, 경량 배터리와 커패시터 전극 잠재적으로 유용하다. 전기 장치에 전기 활성 고분자의 1 개 건물, 자동차, 선글라스, 보호 안경, 광학 저장 장치, 스마트 섬유에 대한 눈부심 감소 시스템을 포함한다. 2-5 스마트 윈도우는 온 디맨드 빛의 특정 파장을 차단하고 집과 자동차의 내부를 보호하여 에너지 요구 사항을 줄일 수 있습니다. 스마트 섬유는 자외선에 대한 보호하기 위해 의류에 사용할 수있다. (6) 전기 활성 고분자는 루게릭 병을 가지고O 의료 기기에 사용되기 시작. 생체 의학 장치에 사용되는 전기 활성 고분자 중에서도, 폴리피롤 (PPy) 계로 이루어 지거나, 폴리아닐린 (PANI) 및 폴리 (3,4- 에틸렌 디옥 시티 오펜) (PEDOT)이 가장 일반적인들이다. 예를 들어, 이러한 유형의 중합체는 일반적으로 바이오 센서 소자의 센서로서 사용되는 치료 용 전달 7 응용 가능성을 또한 보여 주었다.; 연구는 전기 활성 고분자로부터 제조 장치에서 약물과 치료 단백질의 방출을 보여 주었다. 8-12 최근 전기 활성 폴리머는 광열 치료에 치료제로서 사용되어왔다. 13-15 광열 치료에, 광열 에이전트 근처에서 광을 흡수해야 또한 일반적으로 광이 1cm까지. (16, 17)이 범위, 조직 침투 깊이가 최대 치료 창으로 알려진 - 적외선 (NIR) 영역 (~ 700-900 ㎚), 헤모글로빈 등의 생물학적 발색단 산소화 헤모글로빈, 지질 및 물이 거의없는 투빛을 흡수 할 수 있습니다 쉽게 침투한다. 광열 치료 요원이 창에서 빛을 흡수하면, photoenergy은 광열 에너지로 변환된다. 네기시 커플 링을 이용하여 합성 하였다 비스 벤젠 EDOT 단량체, 치환 알콕시 어빈과 동료들은 이전에보고했다. 18 네기 결합은 탄소 - 탄소 결합 형성을위한 바람직한 방법이다. 이 프로세스는 덜 독성 및 다른 유기 금속을 사용보다 높은 반응성을 갖는 경향이 유기 아연 중간체의 사용을 포함하여 많은 장점을 갖는다. 19,20 유기 아연 화합물과 같은 유기 할 작용기의 광범위와 호환된다. (20)에서 네기시 커플 링 반응이, 오르 가노 할라이드 및 유기 금속은 팔라듐 (0) 촉매의 사용을 통해 연결된다. (20) 본원에 제시된 일,이 가교 결합 방법은 (1,4- 디 알콕시 -2,5- 비스의 합성에 이용된다 3,4-ethylenedioxythienyl) - 벤젠NE (BEDOT-B (OR) 2) 단량체. 이들 단량체는 용이하게 생물 의학 응용에 사용하기위한 유망한 후보 중합체를 수득 전기 화학적 또는 화학적으로 중합 될 수있다. 생체 의학 애플리케이션 수용액 콜로이드 중합체 현탁액의 제조를위한 종래의 방법은 일반적으로 폴리 NP에 제조하기 위해서는 nanoprecipitation 또는 에멀젼 용매 증발 기술에 의해. 21,22이어서 벌크 중합체의 용해에 수반 () BEDOT-B (OR 2) NPS 값 시츄 에멀젼 중합을 통해 합성되는 경우, 상향식 접근법은 여기에 설명된다. 에멀젼 중합이 쉽게 확장되고 NP 준비를위한 비교적 빠른 방법이다 공정이다. 다른 전기 활성 폴리머 NPS를 생성하기 에멀젼 중합을 이용하여 22 연구가 된 PPy과 PEDOT에 대해보고되었다. 15,23,24 PEDOT NP는, 예를 들면, 스프레이 에멀젼 (P)을 사용하여 제조 된olymerization. (24)이 방법을 재현하는 것이 곤란하며, 일반적으로 큰 미크론 사이즈의 입자를 산출한다. 이 문서에서 설명하는 프로토콜은 재현성 100 나노 고분자 NPS를 준비하는 드롭 초음파 방법의 사용을 탐구한다. 이 프로토콜에서, 전기 활성 중합체는 이전에보고 된 폴리 유사한 NIR 영역에서 빛을 흡수하기 위해 원단 (BEDOT-B (OR)를 2) 합성 및 전기 장치와 PTT 에이전트로 자신의 잠재력을 입증하기 위해 특징으로한다. 우선, 네기시 커플 링에 의해 단량체의 합성을위한 프로토콜이 설명된다. 단량체는 NMR 및 UV-힘 근적외선 분광법을 사용하여 특징이다. 수성 매질에서 산화 에멀젼 중합을 통해 NP 콜로이드 현탁액의 제조 또한 기술되어있다. 절차는 이전 한 동부 등. 다른 단량체에 적용하여 설명 두 단계 에멀젼 중합 공정에 기초한다. 두 활성제 시스템이다NP의 단 분산을 제어하기 위해 사용된다. 세포 생존력 분석법 된 NP의 cytocompatibility을 평가하는 데 사용된다. 마지막으로, PTT 변환기로서 작용하는 이들의 NP에 전위 NIR 레이저 조사에 의해 증명된다.

<table><tbody><tr><td>2 mm diameter platinum working electrode</td><td>CH Instruments</td><td>CH102</td><td>Polished using very fine sandpaper</td></tr><tr><td>3,4-ethylenedioxythiophene</td><td>Sigma-Aldrich</td><td>483028</td><td>Purified by vacuum distillation</td></tr><tr><td>3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) 98%</td><td>Alfa Aesar</td><td>L11939</td><td></td></tr><tr><td>505 Sonic Dismembrator</td><td>Fisher Scientific&amp;trade;&amp;nbsp;</td><td>FB505110</td><td>1/8&amp;ldquo; tip and rated at 500&amp;nbsp;watts</td></tr><tr><td>808 nm laser diode</td><td>ThorLabs</td><td>L808P1WJ</td><td>Rated at 1 W</td></tr><tr><td>Acetonitrile anhydrous 99%</td><td>Acros</td><td>61022-0010</td><td></td></tr><tr><td>Avanti J-26 XPI</td><td>Beckman Coulter</td><td>393127</td><td></td></tr><tr><td>Bromohexane 98%</td><td>MP Biomedicals</td><td>202323</td><td></td></tr><tr><td>Dialysis (100,000) MWCO</td><td>SpectrumLabs</td><td>G235071</td><td></td></tr><tr><td>Dimethyl sulfoxide 99% (DMSO)</td><td>BDH</td><td>BDH1115</td><td></td></tr><tr><td>Dimethylformamide anhydrous (DMF) 99%</td><td>Acros</td><td>326870010</td><td></td></tr><tr><td>Dodecyl benzenesulfonate (DBSA)&amp;nbsp;</td><td>TCI</td><td>D0989</td><td></td></tr><tr><td>Dulbecco&amp;rsquo;s modified eagle medium (DMEM)&amp;nbsp;</td><td>Corning</td><td>10-013 CV</td><td></td></tr><tr><td>EMS 150 TES sputter coater</td><td>Electron Microscopy Sciences</td><td></td><td></td></tr><tr><td>Ethanol (EtOH) 100%</td><td>BDH</td><td>BDH1156</td><td></td></tr><tr><td>ethyl 4-bromobutyrate (98%)</td><td>Acros</td><td>173551000</td><td></td></tr><tr><td>Ethyl acetate 99%</td><td>Fisher</td><td>UN1173</td><td></td></tr><tr><td>Fetal bovine serum (FBS)</td><td>Corning</td><td>35-010-CV</td><td></td></tr><tr><td>Helios NanoLab 400</td><td>FEI</td><td></td><td></td></tr><tr><td>Hexane</td><td>Fisher</td><td>H306-4</td><td></td></tr><tr><td>Hydrochloric acid (HCl)</td><td>Fisher</td><td>A142-212</td><td></td></tr><tr><td>Hydroquinone 99.5%</td><td>Acros</td><td>120915000</td><td></td></tr><tr><td>Hydrozine anhydrous 98%</td><td>Sigma-Aldrich</td><td>215155</td><td></td></tr><tr><td>Indium tin oxide (ITO) coated galss</td><td>Delta Technologies</td><td>CG-41IN-CUV</td><td>4-8 &amp;Omega;/sq</td></tr><tr><td>Iron chloride 97% FeCl&lt;sub&gt;3&lt;/sub&gt;</td><td>Sigma-Aldrich</td><td>157740</td><td></td></tr><tr><td>Magnesium sulfate (MgSO&lt;sub&gt;4&lt;/sub&gt;)</td><td>Fisher</td><td>593295</td><td>Dried at 100 &amp;#176;C</td></tr><tr><td>SKOV-3</td><td>ATCC</td><td>HTB-26</td><td></td></tr><tr><td>Methanol</td><td>BDH</td><td>BHD1135</td><td></td></tr><tr><td>n-Butlithium (2.5 M)&amp;nbsp;</td><td>Sigma-Aldrich</td><td>230707</td><td>Pyrophoric</td></tr><tr><td>Poly(styrenesulfonate-co-malic acid) (PSS-co-MA) 20,000 MW</td><td>Sigma-Aldrich</td><td>434566</td><td></td></tr><tr><td>Potassium carbonate</td><td>Sigma-Aldrich</td><td>209619</td><td>Dried at 100 &amp;#176;C</td></tr><tr><td>Potassium hydroxide</td><td>Alfa Aesar</td><td>A18854</td><td></td></tr><tr><td>Potassium iodide</td><td>Fisher</td><td>P410-100</td><td></td></tr><tr><td>RO-5 stirplate</td><td>IKA-Werke</td><td></td><td></td></tr><tr><td>SC4000 IR camera</td><td>FLIR</td><td></td><td></td></tr><tr><td>Synergy H4 Hybrid Reader</td><td>Biotek</td><td></td><td></td></tr><tr><td>Tetrabutylammonium perchlorate (TBAP) 99%</td><td>Sigma-Aldrich</td><td>3579274</td><td>Purified by recrystallization in ethyl acetate</td></tr><tr><td>Tetrahydrofuran anhydrous (THF) 99%</td><td>Sigma-Aldrich</td><td>401757</td><td></td></tr><tr><td>tetrakis(triphenylphosphine) palladium(0)</td><td>Sigma-Aldrich</td><td>216666</td><td>Moisture sensitive</td></tr><tr><td>Thermomixer</td><td>Eppendorf</td><td></td><td></td></tr><tr><td>USB potentiostat/galvanostat</td><td>WaveNow</td><td>AFTP1</td><td></td></tr><tr><td>Zetasizer Nano Zs</td><td>Malvern</td><td></td><td>Optical Arrangment 175&amp;#176;</td></tr><tr><td>Zinc chloride (1 M) ZnCl&lt;sub&gt;2&lt;/sub&gt;</td><td>Acros</td><td>370057000</td><td></td></tr></tbody></table>

electroactive polymer nanoparticles exhibiting photothermal properties

A method for the synthesis of electroactive polymers is demonstrated, starting with the synthesis of extended conjugation monomers using a three-step process that finishes with Negishi coupling. Negishi coupling is a cross-coupling process in which a chemical precursor is first lithiated, followed by transmetallation with ZnCl2. The resultant organozinc compound can be coupled to a dibrominated aromatic precursor to give the conjugated monomer. Polymer films can be prepared via electropolymerization of the monomer and characterized using cyclic voltammetry and ultraviolet-visible-near infrared (UV-Vis-NIR) spectroscopy. Nanoparticles (NPs) are prepared via emulsion polymerization of the monomer using a two-surfactant system to yield an aqueous dispersion of the polymer NPs. The NPs are characterized using dynamic light scattering, electron microscopy, and UV-Vis-NIR-spectroscopy. Cytocompatibility of NPs is investigated using the cell viability assay. Finally, the NP suspensions are irradiated with a NIR laser to determine their effectiveness as potential materials for photothermal therapy (PTT).

M1과 M2를 산출 반응 프로토콜은도 1에 도시되어있다. 모노머는 융점, 1 H, 13 C NMR 스펙트럼을 특징으로하고, 원소 분석을 할 수있다. 1 H NMR 스펙트럼은 원자들이 전자 환경의 연결성에 관한 정보를 제공한다; 따라서, 일상적 반응이 성공적으로 완료되었는지 확인하는 데 사용됩니다. 네기시 커플 링 반응은 7.1 ppm으로 7.8 ppm으로 시프트 ?...

Watch this Scientific Journal Video about Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties at JoVE.com

Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties

A protocol is presented for the synthesis and preparation of nanoparticles consisting of electroactive polymers.

전기 활성 고분자 나노 입자 출전 광열 등록

A method for the synthesis of electroactive polymers is demonstrated, starting with the synthesis of extended conjugation monomers using a three-step ...

electroactive-polymer-nanoparticles-exhibiting-photothermal-properties

Research

JoVE Journal

Engineering

13.7K 조회수.  Texas State University. A protocol is presented for the synthesis and preparation of nanoparticles consisting of electroactive polymers. 

비디오: Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties

A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles

In this protocol, we first describe a procedure to synthesize lanthanide doped upconverting nanoparticles (UCNPs). We then demonstrate how to generate amphiphilic polymers in situ, and describe a protocol to encapsulate the prepared UCNPs and different organic dye molecules (porphyrins and diarylethenes) using polymer shells to form stable water-dispersible nanoassemblies. The nanoassembly samples containing both the UCNPs and the diarylethene organic dyes have interesting photochemical and photophysical properties. Upon 365 nm UV irradiation, the diarylethene group undergoes a visual color change. When the samples are irradiated with visible light of another specific wavelength, the color fades and the samples return to the initial colorless state. The samples also emit visible light from the UCNPs upon irradiation with 980 nm near-infrared light. The emission intensity of the samples can be tuned through alternate irradiation with UV and visible light. Modulation of fluorescence can be performed for many cycles without observable degradation of the samples. This versatile encapsulation procedure allows for the transfer of hydrophobic molecules and nanoparticles from an organic solvent to an aqueous medium. The polymer helps to maintain a lipid-like microenvironment for the organic molecules to aid in preservation of their photochemical behavior in water. Thus this method is ideal to prepare water-dispersible photoresponsive systems. The use of near-infrared light to activate upconverting nanoparticles allows for lower energy light to be used to activate photoreactions instead of more harmful ultraviolet light.

Organic dye molecules and oleic acid coated upconverting nanoparticles are not water-soluble. This protocol describes a &#8216;plug and play&#8217; method that enables the transfer of organic dye molecules and upconverting particles from their initial hydrophobic solvent to water.

&#39;플러그 앤 플레이&#39;방법은 양친 매성 고분자, 유기 염료 및 업 컨버팅 나노 입자를 포함하는 수분 산성 Nanoassemblies 만들기

In this protocol, we first describe a procedure to synthesize lanthanide doped upconverting nanoparticles (UCNPs). We then demonstrate how to generate ...

연구

화학

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

In this article a method for the fabrication and reproducible in-vitro evaluation of conducting polymer nanoparticles blended with fullerene as the next generation photosensitizers for Photodynamic Therapy (PDT) is reported. The nanoparticles are formed by hydrophobic interaction of the semiconducting polymer MEH-PPV (poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]) with the fullerene PCBM (phenyl-C61-butyric acid methyl ester) in the presence of a non-compatible solvent. MEH-PPV has a high extinction coefficient that leads to high rates of triplet formation, and efficient charge and energy transfer to the fullerene PCBM. The latter processes enhance the efficiency of the PDT system through fullerene assisted triplet and radical formation, and ultrafast deactivation of MEH-PPV excited stated. The results reported here show that this nanoparticle PDT sensitizing system is highly effective and shows unexpected specificity to cancer cell lines.

This protocol describes a method for the fabrication of conducting polymer nanoparticles blended with fullerene. These nanoparticles were investigated for their potential use as a next generation photosensitizers for Photodynamic Therapy (PDT).

혼합 폴리머 / 풀러렌 나노 입자 감광제를 실시와 광 역학 치료

In this article a method for the fabrication and reproducible in-vitro evaluation of conducting polymer nanoparticles blended with fullerene as the next ...

Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating

One of the most widely used methods for manufacturing colloidal gold nanospherical particles involves the reduction of chloroauric acid (HAuCl4) to neutral gold Au(0) by reducing agents, such as sodium citrate or sodium borohydride. The extension of this method to decorate iron oxide or similar nanoparticles with gold nanoparticles to create multifunctional hybrid Fe2O3-Au nanoparticles is straightforward. This approach yields fairly good control over Au nanoparticle dimensions and loading onto Fe2O3. Additionally, the Au metal size, shape, and loading can easily be tuned by changing experimental parameters (e.g., reactant concentrations, reducing agents, surfactants, etc.). An advantage of this procedure is that the reaction can be done in air or water, and, in principle, is amenable to scaling up. The use of such optically tunable Fe2O3-Au nanoparticles for hyperthermia studies is an attractive option as it capitalizes on plasmonic heating of gold nanoparticles tuned to absorb light strongly in the VIS-NIR region. In addition to its plasmonic effects, nanoscale Au provides a unique surface for interesting chemistries and catalysis. The Fe2O3 material provides additional functionality due to its magnetic property. For example, an external magnetic field could be used to collect and recycle the hybrid Fe2O3-Au nanoparticles after a catalytic experiment, or alternatively, the magnetic Fe2O3 can be used for hyperthermia studies through magnetic heat induction. The photothermal experiment described in this report measures bulk temperature change and nanoparticle solution mass loss as functions of time using infrared thermocouples and a balance, respectively. The ease of sample preparation and the use of readily available equipment are distinct advantages of this technique. A caveat is that these photothermal measurements assess the bulk solution temperature and not the surface of the nanoparticle where the heat is transduced and the temperature is likely to be higher.

Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating

We describe the synthesis and properties of multifunctional Fe2O3-Au nanoparticles produced by a wet chemical approach and investigate their photothermal properties using laser irradiation. The composite Fe2O3-Au nanoparticles retain the properties of both materials, creating a multifunctional structure with excellent magnetic and plasmonic properties.

다기능 하이브리드 철<sub&gt; 2</sub&gt; O<sub&gt; 3</sub&gt; 효율적인 플라즈몬 난방을위한 -Au 나노 입자

One of the most widely used methods for manufacturing colloidal gold nanospherical particles involves the reduction of chloroauric acid (HAuCl4) to ...

공학

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

We recently developed porphysomes as intrinsically multifunctional nanovesicles. A photosensitizer, pyropheophorbide &alpha;, was conjugated to a phospholipid and then self-assembled to liposome-like spherical vesicles. Due to the extremely high density of porphyrin in the porphyrin-lipid bilayer, porphysomes generated large extinction coefficients, structure-dependent fluorescence self-quenching, and excellent photothermal efficacy. In our formulation, porphysomes were synthesized using high pressure extrusion, and displayed a mean particle size around 120 nm. Twenty-four hr post-intravenous injection of porphysomes, the local temperature of the tumor increased from 30 &deg;C to 62 &deg;C rapidly upon one minute exposure of 750 mW (1.18 W/cm2), 671 nm laser irradiation. Following the complete thermal ablation of the tumor, eschars formed and healed within 2 weeks, while in the control groups the tumors continued to grow and all reached the defined end point within 3 weeks. These data show how porphysomes can be used as potent photothermal therapy (PTT) agents.

We developed novel intrinsic multifunctional nanovesicles called porphysomes, which have structure-dependent fluorescence self-quenching and unique photothermal properties, thus functioning as potent photothermal therapy agents. We formulated porphysomes using high pressure extrusion and investigated their photothermal therapy efficacy in a xenograft tumor model.

한 분, Porphysomes를 사용하여 하위 한 와트 광열 종양 절제, 내장 다기능 Nanovesicles

We recently developed porphysomes as intrinsically multifunctional nanovesicles. A photosensitizer, pyropheophorbide &alpha;, was conjugated to a ...

생체공학

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Hybrid interfaces between organic semiconductors and living tissues represent a new tool for in-vitro and in-vivo applications. In particular, conjugated polymers display several optimal properties as substrates for biological systems, such as good biocompatibility, excellent mechanical properties, cheap and easy processing technology, and possibility of deposition on light, thin and flexible substrates. These materials have been employed for cellular interfaces like neural probes, transistors for excitation and recording of neural activity, biosensors and actuators for drug release. Recent experiments have also demonstrated the possibility to use conjugated polymers for all-optical modulation of the electrical activity of cells. Several in-vitro study cases have been reported, including primary neuronal networks, astrocytes and secondary line cells. Moreover, signal photo-transduction mediated by organic polymers has been shown to restore light sensitivity in degenerated retinas, suggesting that these devices may be used for artificial retinal prosthesis in the future. All in all, light sensitive conjugated polymers represent a new approach for optical modulation of cellular activity.
In this work, all the steps required to fabricate a bio-polymer interface for optical excitation of living cells are described. The function of the active interface is to transduce the light stimulus into a modulation of the cell membrane potential. As a study case, useful for in-vitro studies, a polythiophene thin film is used as the functional, light absorbing layer, and Human Embryonic Kidney (HEK-293) cells are employed as the biological component of the interface. Practical examples of successful control of the cell membrane potential upon stimulation with light pulses of different duration are provided. In particular, it is shown that both depolarizing and hyperpolarizing effects on the cell membrane can be achieved depending on the duration of the light stimulus. The reported protocol is of general validity and can be straightforwardly extended to other biological preparations.

A method for stimulation of in-vitro cell cultures electrical activity with visible light, based on the use of organic semiconducting polymers is described.

공액 고분자에 의해 세포를 전기적 활동을 생활의 광 제어

Hybrid interfaces between organic semiconductors and living tissues represent a new tool for in-vitro and in-vivo applications. In particular, conjugated ...

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Magnetically and thermally sensitive poly(N-isopropylacrylamide) (PNIPAAm)/Fe3O4-NH2 microgels with the encapsulated anti-cancer drug curcumin (Cur) were designed and fabricated for magnetically triggered release. PNIPAAm-based magnetic microgels with a spherical structure were produced via a temperature-induced emulsion followed with physical-crosslinking by mixing PNIPAAm, polyethylenimine (PEI), and Fe3O4-NH2 magnetic nanoparticles. Because of their dispersity, the Fe3O4-NH2 nanoparticles were embedded inside the polymer matrix. The amine groups exposed on the Fe3O4-NH2 and PEI surface supported the spherical structure by physically crosslinking with the amide groups of the PNIPAAm. The hydrophobic anti-cancer drug curcumin can be dispersed in water after encapsulation into the microgels. The microgels were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and UV-Vis spectral analysis. Furthermore, magnetically triggered release was studied under an external high frequency magnetic field (HFMF). A significant &#34;burst release&#34; of curcumin was observed after applying the HFMF to the microgels due to the magnetic inductive heating (hyperthermia) effect. This manuscript describes the magnetically triggered controlled release of Cur-PNIPAAm/Fe3O4-NH2 encapsulated curcumin, which can be potentially applied for tumor therapy.

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

This manuscript describes the preparation of magnetic and thermal-sensitive microgels via a temperature-induced emulsion without chemical reaction. These sensitive microgels were synthesized by mixing poly(N-isopropylacrylamide) (PNIPAAm), polyethylenimine (PEI) and Fe3O4-NH2 nanoparticles for the potential use in magnetically and thermally triggered drug-release.

자기 및 열에 민감한 폴리 (<em&gt; N</em&gt; - 이소 프로필 아크릴 아미드) 기반의 마그네틱 트리거 리간드 용 젤

Magnetically and thermally sensitive poly(N-isopropylacrylamide) (PNIPAAm)/Fe3O4-NH2 microgels with the encapsulated anti-cancer drug curcumin (Cur) were ...

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells

Recent studies have demonstrated that nerves can be stimulated in a variety of ways by the transient heating associated with the absorption of infrared light by water in neuronal tissue. This technique holds great potential for replacing or complementing standard stimulation techniques, due to the potential for increased localization of the stimulus and minimization of mechanical contact with the tissue. However, optical approaches are limited by the inability of visible light to penetrate deep into tissues. Moreover, thermal modelling suggests that cumulative heating effects might be potentially hazardous when multiple stimulus sites or high laser repetition rates are used. The protocol outlined below describes an enhanced approach to the infrared stimulation of neuronal cells. The underlying mechanism is based on the transient heating associated with the optical absorption of gold nanorods, which can cause triggering of neuronal cell differentiation and increased levels of intracellular calcium activity. These results demonstrate that nanoparticle absorbers can enhance and/or replace the process of infrared neural stimulation based on water absorption, with potential for future applications in neural prostheses and cell therapies.

This protocol outlines how to use the transient heating associated with the optical absorption of gold nanorods to stimulate differentiation and intracellular calcium activity in neuronal cells. These results potentially open up new applications in neural prostheses and fundamental studies in neuroscience.

골드 신경 세포의 자극을 광학 나노로드가 보조

Recent studies have demonstrated that nerves can be stimulated in a variety of ways by the transient heating associated with the absorption of infrared ...

신경과학

Hydrothermal Synthesis of Persistent Luminescent Nanoparticles

Synthesis of Persistent Luminescent Nanoparticles for Rewritable Displays and Illumination Applications

Persistent luminescent nanoparticles (PLNPs) possess the capabilities to maintain extended longevity and robust emission even after the excitation has ceased. PLNPs have been widely used across various domains, including information displays, data encryption, biological imaging, and artistic decoration with sustained and vivid luminosity, providing boundless possibilities for a variety of innovative technology and artistic projects. This protocol focuses on an experimental procedure for the hydrothermal synthesis of PLNPs. The successful synthesis of enduring luminescent nanomaterials with Mn2+ or Cr3+ serving as a luminescent center in Zn2GeO4: Mn (ZGO: Mn) or ZnGa2O4: Cr highlights the universality of this synthetic method. On the other hand, the optical properties of ZGO: Mn can be changed by adjusting the pH of precursor solutions, demonstrating the tunability of the protocol. When charged with ultraviolet (UV) at a wavelength of 365 nm for 3 min and then stopped, PLNPs exhibit the remarkable capacity to generate afterglow efficiently and consistently, which makes them ideal for making two-dimensional rewritable displays and three-dimensional transparent, luminous artworks. This protocol outlined in this paper provides a feasible method for the synthesis of persistent luminescent nanoparticles for further illumination and imaging applications, opening up novel prospects for the fields of science and art.

저자 스포트라이트: 기능성 나노물질을 이용한 바이오이미징 및 치료의 발전

A protocol is presented for the synthesis of persistent luminescent nanomaterials (PLNPs) and their potential applications in rewritable displays and artistic processing utilizing the afterglow effect under ultraviolet light (365 nm) irradiation.

Synthesis of persistent luminescent nanoparticles for rewritable display and illumination applications(재기록 가능한 디스플레이 및 조명 응용을 위한 영구 발광 나노입자의 합성)

Persistent luminescent nanoparticles (PLNPs) possess the capabilities to maintain extended longevity and robust emission even after the excitation has ...

전기 활성 고분자 나노 입자 출전 광열 등록

요약

더 많은 비디오 탐색

이 비디오의 챕터

'플러그 앤 플레이'방법은 양친 매성 고분자, 유기 염료 및 업 컨버팅 나노 입자를 포함하는 수분 산성 Nanoassemblies 만들기

혼합 폴리머 / 풀러렌 나노 입자 감광제를 실시와 광 역학 치료

다기능 하이브리드 철

한 분, Porphysomes를 사용하여 하위 한 와트 광열 종양 절제, 내장 다기능 Nanovesicles

공액 고분자에 의해 세포를 전기적 활동을 생활의 광 제어

자기 및 열에 민감한 폴리 (

골드 신경 세포의 자극을 광학 나노로드가 보조

Synthesis of persistent luminescent nanoparticles for rewritable display and illumination applications(재기록 가능한 디스플레이 및 조명 응용을 위한 영구 발광 나노입자의 합성)

Synthesis of persistent luminescent nanoparticles for rewritable display and illumination applications(재기록 가능한 디스플레이 및 조명 응용을 위한 영구 발광 나노입자의 합성)

Synthesis of persistent luminescent nanoparticles for rewritable display and illumination applications(재기록 가능한 디스플레이 및 조명 응용을 위한 영구 발광 나노입자의 합성)