The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Podsumowanie

Psoriasis is a chronic, immune-mediated inflammatory skin disease. The Goeckerman regimen, formulated for the treatment of psoriasis, consists of exposure to ultraviolet B (UVB) light and application of crude coal tar (CCT). The following protocol is for the administration of Goeckerman therapy for the treatment of moderate-to-severe psoriasis.

Streszczenie

Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting approximately 2-3% of the population. The Goeckerman regimen consists of exposure to ultraviolet B (UVB) light and application of crude coal tar (CCT). Goeckerman therapy is extremely effective and relatively safe for the treatment of psoriasis and for improving a patient's quality of life. In the following article, we present our protocol for the Goeckerman therapy that is utilized specifically at the University of California, San Francisco. This protocol details the preparation of supplies, administration of phototherapy and application of topical tar. This protocol also describes how to assess the patient daily, monitor for adverse effects (including pruritus and burning), and adjust the treatment based on the patient's response. Though it is one of the oldest therapies available for psoriasis, there is an absence of any published videos demonstrating the process in detail. The video is beneficial for healthcare providers who want to administer the therapy, for trainees who want to learn more about the process, and for prospective patients who want to undergo treatment for their cutaneous disease.

Wprowadzenie

Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting approximately 2-3% of the population.¹ One-third of the patients experience generalized psoriasis that causes debilitating physical and psychological effects. The Goeckerman regimen, first published in 1925 for the treatment of generalized psoriasis, consists of exposure to ultraviolet B (UVB) light and application of crude coal tar (CCT).² Though newer internal agents such as biologics have enhanced the treatment of psoriasis, Goeckerman therapy remains as an extremely effective option, while providing a long duration of remission.^3,4 In a published study conducted at UCSF, 100% of patients on Goeckerman therapy achieved PASI75 (75% improvement of Psoriasis Assessment of Severity Index [PASI] from baseline) by 3 months.⁵ In comparison (though not head to head), patients on the most potent biologics achieved only 67-68% PASI75 in 3 months.⁶ The Goeckerman regimen has a quick onset and has been utilized with success in patients with treatment-resistant psoriasis refractory to phototherapy or internal medications.⁷ The Goeckerman regimen also has an extremely safe toxicity profile with essentially no internal side effects, which are the more serious risks associated with other psoriasis treatments. Furthermore, the therapy has been shown to have a significant and positive effect on the quality of life of patients with generalized psoriasis.⁸

Goeckerman regimen was formerly administered 24 hr a day at an inpatient facility until the patient was cleared of their psoriasis. However, due to changes in reimbursements and managed care, patients are now treated in daycare facilities for a minimum of 4-8 hr/day and 5 days/week until their disease clears. Goeckerman therapy was initially formulated for the treatment of psoriasis, but a modified version has recently been used for the treatment of other skin conditions such as eczema with success. The following protocol is utilized at UCSF specifically for psoriasis, but slight changes in the procedures can be tailored for eczema, generalized pruritus, prurigo nodularis, pityriasis lichenoides chronica, erythroderma, and other related skin disorders.⁹

Though it is one of the oldest therapies available for psoriasis, there is an absence of any published videos demonstrating the process. A video can have a broad appeal as it can be used as a resource for referring healthcare practitioners (primary care physicians and dermatologists) to understand the process and feel comfortable recommending the therapy. A video demonstrating the Goeckerman process will also be instrumental for educating residents and medical students who are not exposed to the regimen since there are only a few institutions left that continue to provide this type of intensive therapy. A video will also be beneficial for prospective patients who are interested in receiving Goeckerman therapy.

Protokół

1. Evaluation and Preparation

1. Perform a complete history and physical prior to initiating therapy. In the history and physical, document important information such as current/past medications, response to past psoriasis therapies, any history of adverse reactions to ambient sunlight or phototherapy, severity of pruritus, and sleep quality.
2. Set up a clinic room with all the necessary material for dermal application of medications and occlusion [See Materials Section and Figure 1]. Also, place other materials in the room such as gloves, plastic wrap, socks, and scrubs/pajama gowns.
3. Assess the patient for diffuse and intense erythema prior to starting therapy.
4. If the patient exhibits widespread or intense erythema, perform a "cool down" procedure (see below) until the erythema is significantly reduced. If no widespread or intense erythema is seen, proceed to the "phototherapy + tar" step.

2. Cool Down (If Needed)

1. Apply topical corticosteroids to the affected areas. Apply triamcinolone 0.1% ointment to the trunk and extremities, desonide 0.05% cream/ointment to the face/axillae/groin, and fluocinolone 0.01% oil or triamcinolone 0.1% lotion to the scalp. Reserve clobetasol 0.05% ointment for areas with the most intense inflammation.
2. Occlude the topical medications with plastic wrap for the trunk and extremities, impermeable gloves for the hand and shower caps inside socks for the feet, and a shower cap for the scalp.
3. Cool down the patient until the erythema is significantly reduced (range from 3-14 days).

3. Phototherapy + Tar

1. After the patient finishes the cool down period, administer phototherapy daily in the morning prior to the application of crude coal tar [Figure 2]. Phototherapy options include narrowband UVB (most commonly used in psoriasis) or broadband UVB (most commonly used in eczema). Determine the initial phototherapy dose by Fitzpatrick skin type [see Table 1 and Table 2].
2. Slowly titrate the subsequent phototherapy doses upwards as tolerated. Dosing regimen and schedule need to be individualized based on patient response to phototherapy.
3. After phototherapy, apply 2% crude coal tar (CCT) in aquaphor topically to affected areas of the body [Figure 3]. If patient has scalp involvement, apply 20% liquid carbonis detergens (LCD) in nutraderm to the scalp.
4. Initially, use 2% CCT (lowest strength). On subsequent treatment days, increase the strength of the tar as tolerated by the patient from 2% to 5% and then to 10% to achieve better results.
5. For thickened areas of psoriasis, use tar compounded with salicylic acid (2%/5%/10% salicylic acid) to help reduce the scaling and induration of the plaques. Initially use preparations of 2% salicylic acid with 10% CCT, and titrate the percentage of salicylic acid up as tolerated by the patient on subsequent days. Salicylic acid may be contraindicated in patients with diabetes or gastric ulcers.
6. Occlude topical tar in the same manner as described in step 2.2 for the cooling down procedure.
7. Keep topical medications on the skin for at least 4 hr. After a minimum of 4 hr, remove the occlusion materials and wash off the tar in the shower with mineral oil and soap [Figure 4].
8. Give the patient 20% LCD in aquaphor and 20% LCD in nutraderm to apply on the body and scalp, respectively, at home.
9. Patients with eczema tend to have sensitive skin. Use 2% CCT initially for eczema patients. Be careful when titrating up to 5% CCT, as patients with eczema tend to have sensitive skin. Do not use 10% CCT (or any percentage of CCT higher than 5%) and do not use any preparations with salicylic acid.

4. Daily Assessment

1. Each day, perform an evaluation and assess the patient's skin and response to treatment. Evaluate specifically for sensations of burning, which can indicate the patient's inability to tolerate light therapy, or itching, which can indicate irritation from the tar and/or plastic wrap.
2. If a patient exhibited signs of burning (burning sensation, significant increasing erythema, or rarely increased itch as a harbinger of impending burn if dosimetry is increased further), decrease phototherapy dose or do not give phototherapy that day, as it may have been caused by a phototoxic reaction to the previous UV light dose.
3. It is not uncommon for patients to have different regional anatomical responses and tolerability to phototherapy. For optimal treatment, adjust the amount of phototherapy dose exposed to different regions of the body according to patient's response. For example, if a patient experiences mild burning of the trunk, then first treat the entire body with the lowered phototherapy dose, than cover the trunk, and give additional light to the extremities.

5. Discharge Planning and Maintenance

1. Continue Goeckerman therapy until disease is cleared and patient is ready to be discharged.
2. Place patients on a maintenance program, which can include outpatient phototherapy and topical medications
3. Administer outpatient phototherapy three times a week (for at least the first month). Eventually the frequency is gradually tapered down to twice a week and then once a week)
4. Outpatient topical medications include: Triamcinolone cream/ointment to the body twice daily, Clobetasol to recalcitrant lesions (if needed) twice daily, 20% LCD in aquaphor to the body and 20% LCD in nutraderm to the scalp.
5. Within a month of discharge, schedule a follow up physician visit with the patient to monitor disease state.

Wyniki

In a study performed at our center at the University of California San Francisco, PASI75 response (a 75% improvement in the Psoriasis Assessment Severity Index) was achieved in 100% of patients receiving Goeckerman (n = 25) over a 3-month time period.⁵ 24/25 patients needed only 2 months to achieve PASI75, while the remaining patient obtained a PASI75 response at 3 months. In another study, Menter et al. administered the Goeckerman regimen for 300 patients and 100% of the patients achieved 90% or more...

Dyskusje

The Goeckerman Regimen protocol outlined above is utilized at UCSF and can be varied in multiple ways according to the patient's response to therapy. Since the patient is seen and examined every day, the protocol can be individualized for each patient to ensure maximum efficacy. The traditional Goeckerman treatment solely consisted of the use of CCT and UVB phototherapy.² However, the regimen has been modified to include the use of topical corticosteroids (and at times other topical medications such as calcipo...

Materiały

Name	Company	Catalog Number	Comments
Name of Medication	Company
2% Crude Coal Tar in White Petrolatum or Cetaphil	Compounded at Pharmacy
5% Crude Coal Tar in White Petrolatum or Cetaphil	Compounded at Pharmacy
10% Crude Coal Tar in White Petrolatum +/- 2/5/10% Salicyclic Acid	Compounded at Pharmacy
10% Crude Coal Tar in Cetaphil	Compounded at Pharmacy
20% Liquid Carbonis Detergenis in Nutraderm	Compounded at Pharmacy
20% Liquid Carbonis Detergenis in Aquaphor or Cetaphil	Compounded at Pharmacy
Triamcinolone 0.1% ointment/cream/lotion	Prescription Medication - Generic
Desonide 0.05% cream/ointment	Prescription Medication - Generic
Fluocinolone 0.01% oil	Prescription Medication - Generic
Clobetasol 0.05% ointment/cream	Prescription Medication - Generic
Hydrophillic Ointment	Over the Counter - Generic
Mineral Oil	Over the Counter - Generic
Name of Equipment	Company
Narrow-Band Phototherapy Unit	National Biologic Corporation
Broad-Band Phototherapy Unit	National Biologic Corporation