Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This makes them particularly beneficial for managing chronic constipation and conditions like irritable bowel syndrome (IBS).
On the other hand, stimulant laxatives irritate the intestinal lining, triggering muscle contractions that propel the stool forward. They provide short-term relief from constipation and are beneficial when different laxative types prove ineffective. Typical examples of stimulant laxatives include Senna, an anthraquinone glycoside derivative; bisacodyl (Dulcolax), a diphenylmethane derivative; and castor oil, a source of ricinoleic acid. Senna, which is derived from plants such as Cassia acutifolia or Cassia angustifolia, increases water and electrolyte secretions and may cause abdominal cramping, nausea, and diarrhea as side effects. Bisacodyl is available as enteric-coated tablets and suppositories. Its prolonged use results in mucosal inflammation and colonic ischemia. Castor oil should be avoided by pregnant women, as it stimulates uterine contractions.
From Chapter 22:
Now Playing
Drugs Affecting Gastrointestinal Motility
111 Views
Drugs Affecting Gastrointestinal Motility
170 Views
Drugs Affecting Gastrointestinal Motility
166 Views
Drugs Affecting Gastrointestinal Motility
156 Views
Drugs Affecting Gastrointestinal Motility
144 Views
Drugs Affecting Gastrointestinal Motility
149 Views
Drugs Affecting Gastrointestinal Motility
112 Views
Drugs Affecting Gastrointestinal Motility
111 Views
Drugs Affecting Gastrointestinal Motility
116 Views
Drugs Affecting Gastrointestinal Motility
89 Views
Copyright © 2025 MyJoVE Corporation. All rights reserved