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Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

DOI :

10.3791/4206-v

August 28th, 2012

August 28th, 2012

14,865 Views

1Department of Preventive Medicine, University of Southern California, 2Institute for Women's Health, University College London

We describe methodologies for establishing in vitro heterotypic three-dimensional models comprising ovarian fibroblasts and normal ovarian surface or ovarian cancer epithelial cells. We discuss the use of these models to study stromal-epithelial interactions that occur during ovarian cancer development.

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Heterotypic Three dimensional In Vitro Modeling

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