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A Sensitive Method to Quantify Senescent Cancer Cells

DOI :

10.3791/50494-v

August 2nd, 2013

August 2nd, 2013

20,309 Views

1MILPAT (EA 4652), Université de Caen Basse-Normandie

Whether senescence prevents or promotes tumorigenesis remains controversial. Since chemotherapeutical drugs can induce cancer cells to senesce, studying senescence is essential for proposing new therapies. However, the standard and broadly used β-galactosidase assay presents major drawbacks. We propose here a rapid and sensitive flow cytometry-based assay to quantify senescence.

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Keywords Senescence

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