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Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

DOI :

10.3791/51078-v

March 2nd, 2014

March 2nd, 2014

10,267 Views

1Department of Microbiology and Immunology, Keck School of Medicine, University of Southern California

We describe a protocol to measure the antiviral cytokine production in mice infected with a model herpesvirus, murine gamma herpesvirus 68 (γHV68) that is closely-related to human Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). Utilizing genetically modified mouse strains and mouse embryonic fibroblasts (MEFs), we assessed the antiviral cytokine production both in vivo and ex vivo

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Innate Immune Signaling

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