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Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

DOI :

10.3791/53318-v

December 10th, 2015

December 10th, 2015

7,201 Views

1Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine

Nuclear envelope proteins play a central role in many basic biological processes and have been implicated in a variety of human diseases. This protocol describes a new Cre/Lox-based mouse model that allows for the spatiotemporal control of LINC complexes disruption.

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