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Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models

DOI :

10.3791/53429-v

7:48 min

November 21st, 2015

November 21st, 2015

17,214 Views

1European Cancer Stem Cell Research Institute, Cardiff University, 2Institut Curie

Intestinal epithelial stem cells (ISCs) are intermingled with Paneth cells. These cells are differentiated progeny of the ISC, which support the ISCs and provide antibacterial protection. Here we demonstrate how we used transgenic conditional mouse models to establish that Paneth cells play a crucial role in maintaining the intestinal epithelia.

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Paneth Cells

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