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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

DOI :

10.3791/56926-v

February 16th, 2018

February 16th, 2018

11,731 Views

1Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Univ Paris-Saclay

Chiral amino alcohols are versatile molecules for use as scaffolds in organic synthesis. Starting from L-lysine, we synthesize amino alcohols by an enzymatic cascade reaction combining diastereoselective C-H oxidation catalyzed by dioxygenase followed by cleavage of the carboxylic acid moiety of the corresponding hydroxyl amino acid by a decarboxylase.

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Enzymatic Cascade Reactions

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