Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model

7.5K Views

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10:03 min

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November 21st, 2019

DOI :

10.3791/60450-v

November 21st, 2019

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Rami Ahmad Shahror¹^,²^,³, Chung-Che Wu²^,³^,⁴^,⁵, Yung-Hsiao Chiang¹^,²^,³^,⁴^,⁵, Kai-Yun Chen¹^,²^,³

¹Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, ²Center for Neurotrauma and Neuroregeneration, Taipei Medical University, ³TMU Neuroscience Research Center, Taipei Medical University, ⁴Department of Neurosurgery, Taipei Medical University Hospital, ⁵Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University

Summary

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Superparamagnetic Iron Oxide

Mesenchymal Stem Cells

MRI Tracking

Intranasal Delivery

Traumatic Brain Injury

Non invasive Delivery

Therapeutic Effects

Mesenchymal Stem Cell Labeling

CCI Injury Induction

Stereotactic Frame

Bone Flap Removal

Fluorescent Microscope

T 75 Flask

PBS Washing

Chronic Stage Therapy

Chapters in this video

0:05

Title

1:06

Superparamagnetic Iron Oxide (SPIO) nanoParticles labeling of Mesenchymal Stem Cells (MSC)

1:44

Controlled Cortical Impact (CCI) Injury

4:04

Intranasal MSC Delivery

5:57

In Vivo Magnetic Resonance Imaging (MRI)

6:54

MSC Tracking and Quantification

8:03

Results: Representative SPIO-Labeled MSC Detection and Tracking

9:08

Conclusion

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