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An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

DOI :

10.3791/61577-v

6:02 min

November 2nd, 2020

November 2nd, 2020

5,058 Views

1Department of Medicine, Integrated Cardio Metabolic Centre (ICMC), Heart and Vascular Theme, Karolinska Institutet, 2Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca

This paper presents methods for growing cardiac myocytes with different shapes, which represent different pathologies, and sorting these adherent cardiac myocytes based on their morphology at a single cell level. The proposed platform provides a novel approach to high throughput and drug screening for different types of heart failure.

Tags

Transcriptomics

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