A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
5.3K Views
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07:17 min
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January 29th, 2021
DOI :
January 29th, 2021
•Vincent Law1,2, Margi Baldwin3, Ganesan Ramamoorthi4, Krithika Kodumudi4, Nam Tran1, Inna Smalley5, Derek Duckett6, Pawel Kalinski7, Brian Czerniecki4, Keiran S. M. Smalley2, Peter A. Forsyth1,2
1Department of Neuro-Oncology, H. Lee Moffitt Cancer Center & Research Institute, 2Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, 3Department of Comparative Medicine, University of South Florida, 4Department of Breast Oncology, H. Lee Moffitt Cancer Center & Research Institute, 5Department of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, 6Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, 7Department of Medical Oncology, Roswell Park Comprehensive Cancer Center
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Chapters in this video
0:04
Introduction
1:07
Injection of CTCs into CSF to Generate a Mouse LMD Model
3:37
Murine Ommaya Assembly and Implantation
5:20
Results: Direct-Targeted Immunotherapy Using the Murine Ommaya Increases the Overall Survival of Breast Cancer-Associated Leptomeningeal Disease Mice
6:37
Conclusion
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