JoVE Logo

Sign In

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

3.0K Views

11:47 min

July 6th, 2022

DOI :

10.3791/64122-v

July 6th, 2022


Explore More Videos

Human Aorta

Chapters in this video

0:04

Introduction

1:03

Primary Human Aortic Smooth Muscle Cell Isolation

2:53

Preparation of PDMS Chip

5:29

PDMS Chip Surface Treatment and Sterilization

6:12

Cell Seeding on the PDMS Chip and Cell Stretching Process

8:23

Preparation of the Mechanical Control System

9:30

Results: An HASMC‐Organ‐On‐A‐Chip Model to Precisely Control the Parameters of the Biomechanical Strain on the Aortic Wall

11:03

Conclusion

Related Videos

article

08:00

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

19.0K Views

article

12:13

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

10.8K Views

article

16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

11.7K Views

article

10:01

Microfluidic Model to Mimic Initial Event of Neovascularization

4.6K Views

article

10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

4.9K Views

article

09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

3.3K Views

article

09:46

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

1.6K Views

article

12:28

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

1.0K Views

article

06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

8.3K Views

article

08:28

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

3.5K Views

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2025 MyJoVE Corporation. All rights reserved