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Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues (Video) | JoVE

DOI :

10.3791/64368-v

June 2nd, 2023

June 2nd, 2023

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1Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai

Three-dimensional cardiac tissues bioengineered using stem-cell-derived cardiomyocytes have emerged as promising models for studying healthy and diseased human myocardium in vitro while recapitulating key aspects of the native cardiac niche. This manuscript describes a protocol for fabricating and analyzing high-content engineered cardiac tissues generated from human induced pluripotent stem-cell-derived cardiomyocytes.

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