Compared with Taohong Siwu Tang Wan traditional decoction, the production, in the form of dispersible tablets has many advantage and certain innovation, which provide a new choice for clinical use. It is possible to prepare traditional Chinese medicines decoctions into your modern dosage form in a relatively simple and easy to operate manner. The traditional Chinese medicine decoction, Taohong Siwu Tang Wen, is widely used in clinical practice, orthopedics and gynecology.
But has a disadvantage of inconvenience, having long decoction time, et cetera. And the preparation of dispersible tablets can certainly overcome that, providing a new choice for clinical medicine. To begin, measure prepared Rehmannia root, peach kernel, Safflower, Angelica, white peony, and Ligusticum Chuan Xiong.
And place these ingredients in a decoction casserole. Add 1, 683 milliliters of water. And boil the ingredients for 1.5 hours.
After repeating the decoction three times, combine all the filtrate. Then, filter the resultant liquid with a gauge. And concentrate it in a rotary evaporator to a final volume of 400 milliliters.
Once evaporated, evenly pour the concentrate into an evaporation dish. And place it in a water bath at 90 degrees Celsius to dry the excess water. Then, place the thickened extract in a vacuum drying oven to obtain a dry extract.
Subsequently, grind the dried extract into a powder in a mortar. And then sieve with an 80 mesh sieve. To screen the fillers, prepare the first formula.
By mixing 0.5 grams of medicinal powder. 3.4 grams of microcrystalline cellulose as filler. 1 gram of PVPP as the disintegrant.
And 0.1 grams of magnesium stearate as the lubricant. Similarly, after preparing the other two formulas, with the pre-gelatinized starch and lactose as fillers, mix each prescription thoroughly. And pass through an 80 mesh sieve.
Place the evenly mixed powder into a single punch tablet machine. And punch out a tablet. Place the beaker containing one liter of distilled water into a dissolution tester.
And test each tablet separately, by adding the tablet into a beaker, containing one liter of distilled water, tempered at 37 degrees Celsius. Start the dissolution tester and the timer. When the tablets are completely dissolved, stop the timer.
And observe whether the tablets are evenly dispersed. Fill a one liter beaker with approximately 37 degrees Celsius water, before placing it in the disintegration tester. Hang a gondola on a bracket with a stainless steel shaft at the upper end.
Immerse the apparatus in a one liter beaker. Adjust the position of the gondola, such that the screen is 25 millimeters from the bottom of the beaker when it drops to its lowest point. Then, adjust the height of the water level such that the sieve is 15 millimeters below the water surface when the gondola rises to its highest point.
Ensure that the top of the gondola is not submerged in solution at any point. Take six tablets from each test batch, and place them in a glass tube on the gondola. Activate the disintegration tester.
And monitor the disintegration of all the tablets. Repeat the disintegration if all tablets do not dissolve in 15 minutes. The filler screening results showed that the disintegration time with lactose was better than pre-gelatinized starch, and microcrystalline cellulose.
However, the hardness and surface finish did not meet the required standards. Thus, microcrystalline cellulose was selected as the filler. Further, taking appearance, disintegration time, and dispersion uniformity, as the inspection indicators.
The combined disintegration time and dispersion uniformity of cross-linked polyvinylpyrrolidone and sodium was found to be optimal. After obtaining the optimal filler and disintegrate content, using orthogonal testing, the four prescriptions were prepared by varying amount of herbal powder. Before, prescriptions passed the dispersion uniformity assessment.
However, a larger drug load results in a longer disintegration time and reduces hardness. In experiments, the concentrated volume of the original solution is critical for subsequent active ingredient testing. For evaporation of more concentrated than water, it is essential to use a vacuum drawing oven to avoid volatilization of the active ingredients.
In the follow up of this experiment, animal experiments can be carried out to compare the efficacy of the traditional dosage form, to clarify whether the efficacy of the new dosage forms is different from the traditional dosage form, and provide theoretical support for clinical use.
