A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
Results: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
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Conclusion
副本
This protocol is a large animal model for studying right ventricular adaptation and failure. This model is therefore vital for developing RV-targeted therapeutics to treat pulmonary hypertension. This model progressively increases the right RV aft
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This manuscript describes the surgical technique and experimental approach to develop severe right ventricular pressure overload to model their adaptive and maladaptive phenotypes.