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JoVE Journal

Medicine

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Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

16.0K Views

07:44 min

August 7th, 2015

August 7th, 2015

15,986 Views

0:05

Title

1:46

Pancreatic Duct Ligation (PDL)

4:08

PDL/Sham Pancreas Tail Harvest

5:17

Results: PDL Induces Acinar Atrophy and Inflammation without Affecting Bodyweight and Glycemia

7:00

Conclusion

This protocol describes an injury model involving the surgical ligation of the pancreatic duct in the adult mouse pancreas, resulting in severe injury that establishes an environment that allows beta cell neogenesis and proliferation. This model can be used as a tool to study mechanisms involved in beta cell formation.

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