Results: Evaluation of Anti-Depressive Interventions
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Conclusion
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The chronic despair model represents a suitable model for the induction of a chronic depressive-like state in mice in order to better understand the path of physiology of mood disorders and to evaluate potential antidepressive treatment interventi
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The chronic despair mouse model (CDM) of depression consists of repetitive forced swim sessions and another delayed swim phase as a read-out. It represents a suitable model for induction of a chronic depressive-like state stable for at least 4 weeks, amendable to evaluate subchronic and acute treatment interventions.