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A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

DOI :

10.3791/63657-v

March 23rd, 2022

March 23rd, 2022

2,230 Views

1Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University

A procedure that demonstrates a robust acute food deprivation-induced relapse to heroin seeking after punishment-imposed abstinence is described. A punishment-imposed abstinence model was successfully implemented using the seek and take chain schedule for heroin self-administration. Heroin-seeking tests are then performed following 24 h of food-deprivation stress.

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