Chapter 7
Pharmacokinetic Models
약동학 데이터의 분석 방법: 모델 및 모델 독립적 접근 방식
The drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The ...
약동학 데이터에 대한 모델 접근법: 구획 모델
Compartmental analysis is a commonly used approach to characterize drug pharmacokinetics.
Compartment models assume the body as a series of reversibly ...
IV 볼루스 투여를 위한 One-Compartment Open Model: 일반적인 고려 사항
A one-compartment open pharmacokinetic model describes the drug concentration-time course in the body post-administration. It views the body as a single, ...
IV 볼루스 투여를 위한 One-compartment open model: 제거율 상수, 반감기 및 분포량 추정
The one-compartment open model for IV bolus drug administration considers drug elimination as a monoexponential process.
Analyzing the plasma drug ...
IV 볼루스 투여를 위한 One-compartment open 모델: 청소율 추정
Clearance signifies the theoretical fluid volume from which a drug is completely removed within a specific timeframe, expressed as volume per unit time. ...
1격실 모델: IV 주입
IV infusion is suitable when maintenance of constant and stable drug concentration in the body is desired or when the drug poses toxicity risks.
For ...
혈관외 투여를 위한 One-compartment open model: zero-order absorption 모델
Extravascular drug administration occurs via oral, intramuscular, or rectal routes.
It relies on absorption for the drug's therapeutic activity.
Here, ...
혈관외 투여를 위한 One-compartment open model: First-Order Absorption 모델
The first-order absorption model for extravascular administration considers the rate at which a drug is absorbed, distributed in body tissues, and ...
1구획 개방 모델: ka 추정을 위한 Wagner-Nelson 및 Loo Riegelman 방법
The Wagner-Nelson method estimates the absorption rate constant, ka, for drugs administered without assuming zero- or first-order absorption.
Its ...
One-Compartment Open Model: 비뇨기 배설 데이터 및 k의 결정
Urinary excretion data helps understand the process of drug elimination from the body, providing insight into the clearance of unaltered drugs.
It is a ...
Multicompartment 모델: 개요
Multicompartment models illustrate how drugs are distributed and eliminated within the body. They offer a more accurate depiction than one-compartment ...
Two-Compartment Open 모델: 개요
Multicompartment pharmacokinetic models illustrate drug distribution and elimination within the body.
The most common type of these models is the ...
2격실 개방형 모델: IV 볼루스 투여
The two-compartment model for intravenous bolus administration comprises central and peripheral compartments, representing the distribution of a drug in ...
2 격실 개방형 모델 : IV 주입
Two-compartment models are pharmacokinetic tools to understand drug distribution.
For a drug administered via a constant rate or zero-order intravenous ...
Two-Compartment Open Model: 혈관외 투여
Two-compartment models for extravascular administration involve a central and a peripheral compartment.
For a drug entering the body via a first-order ...
3칸 개방형 모델
Three-compartment models are similar to the two-compartment model but have an additional deep tissue compartment.
The deep tissue compartment represents ...
Mechanistic Models: 구획 모델 개요
Pharmacokinetic models can be classified as empirical or mechanistic.
Empirical models include data description with minimal assumptions about the ...
Mechanistic Models: Compartment Models in Individual and Population Analysis
The individual analysis uses mechanistic models involving single-source data. However, data collection errors prevent perfect observed data prediction.
In ...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
Mechanistic models use numerical problem-solving algorithms to evaluate parameters.
Some algorithms use linearization techniques to simplify the model ...
약동학 데이터에 대한 모델 접근법: 생리학적 모델
Physiological models illustrate the drug's distribution and elimination processes within the body.
They describe the drug concentration in target ...
생리학적 약동학 모델: 단백질 결합을 통한 가정
Physiological models can predict drug disposition assuming linear drug-protein interactions.
Compared to conventional models, they effectively predict ...
생리학적 약동학 모델: 혈류 제한 모델 대 확산 제한 모델
Physiological models generally postulate a swift drug distribution between tissue and venous blood.
Rapid drug equilibrium assumes quick drug diffusion ...
생리학적 약동학 모델: 간 수송체 매개 청소율 통합
Drug transporters are pivotal in drug absorption, distribution, and excretion processes and should be included in physiologically-based pharmacokinetic ...
약동학 데이터에 대한 모델 접근법: 분포 모수 모델
Pharmacokinetic models employ mathematical expressions for predicting drug behavior in the body and calculating pharmacokinetic parameters.
Different ...
약동학 데이터에 대한 모델 독립적 접근법: 비구획 분석
Noncompartmental analysis is an alternative method for describing drug pharmacokinetics without assigning a particular compartmental model to the drug.
...
비구획 분석: 통계적 모멘트 이론
Noncompartmental analyses rely on statistical moment theory to examine time-related changes in macroscopic events. Mean residence time, MRT, describes the ...
비구획 분석: 평균 체류 시간
According to statistical moment theory, mean residence time is the expected mean of a probability density function distribution. It can also be viewed ...
비구획 분석: 평균 통과, 흡수 및 용해 시간
When drugs are administered extravascularly, various parameters are considered for noncompartmental analysis.
The mean transit time, MTT, is the total ...
비구획 분석: 기타 약동학 파라미터
The noncompartmental approach utilizes various factors, including clearance, bioavailability, and total volume of distribution.
Once a drug is ...
약동학 모델: 비교 및 선택 기준
Physiological and compartmental models used to study biological systems rely on differential equations for mass balance.
Physiological models consider ...
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