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JoVE Journal

Neuroscience

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Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

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07:32 min

June 23rd, 2014

June 23rd, 2014

14,267 Views

0:05

Title

1:52

Oxygen Induced Retinopathy (OIR) and Intravitreal Injection

2:51

Assessment of Vessel Perfusion and Barrier Function by Fluorescein Angiography

3:29

Enucleation and Eye Fixation

4:16

Retinal Dissection

5:11

Retinal Vascular Staining

6:13

Results: Vascular Regeneration in the Mouse Retina

6:46

Conclusion

The rodent retina has long been recognized as an accessible window to the brain. In this technical paper we provide a protocol that employs the mouse model of oxygen-induced retinopathy to study the mechanisms that lead to failure of vascular regeneration within the central nervous system after ischemic injury. The described system can also be harnessed to explore strategies to promote regrowth of functional blood vessels within the retina and CNS.

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