This method employs topical application of nanoparticles to image microscopic tumors, especially in malignancies that do not yet have access to the vasculature, such as the metastasis of ovarian cancer. This technique is ratiometric, imaging targe
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Ovarian cancer forms metastases throughout the peritoneal cavity. Here, we present a protocol to make and use folate-receptor targeted surface-enhanced resonance Raman scattering nanoprobes that reveal these lesions with high specificity via ratiometric imaging. The nanoprobes are administered intraperitoneally to living mice, and the derived images correlate well with histology.