Results: Representative Effects of Repetitive and Chronic CNO Delivery
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Conclusion
Transcrição
DREADDs are the most popular chemogenetic approach for remote control of neuronal activity. Here we offer new alternatives for repetitive or chronic DREADD control, focusing on less invasive CNO delivery methods. We describe two strategies for the
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Here we describe two non-invasive methods to chronically control neuronal activity using chemogenetics in mice. Eye-drops were used to deliver clozapine-N-oxide (CNO) daily. We also describe two methods for prolonged administration of CNO in drinking water. These strategies for chronic neuronal control require minimal intervention reducing animals’ stress.