The method we are using here can help to package oligonucleotide with single-wall carbon nanotube, which is a new type of nanoparticle for drug delivery. The main advantage of this technique is more efficient delivery of oligonucleotide drugs into
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This manuscript describes the synthesis of a single-wall carbon nanotube (SWCNT)-conjugated MALAT1 antisense gapmer DNA oligonucleotide (SWCNT-anti-MALAT1), which demonstrates the reliable delivery of the SWCNT and the potent therapeutic effect of anti-MALAT1 in vitro and in vivo. Methods used for synthesis, modification, conjugation, and injection of SWCNT-anti-MALAT1 are described.