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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

DOI :

10.3791/50097-v

7:01 min

April 17th, 2013

April 17th, 2013

20,372 Views

1Department of Internal Medicine, Division of Endocrinology, Saint Louis University School of Medicine

Generation of an orthotopic mouse model of anaplastic thyroid carcinoma is described here. This technique employs surgical placement of human anaplastic thyroid cancer cells into the thyroid of immunodeficient mice, thus creating a more clinically relevant setting to study disease progression as well as screen innovative therapeutic interventions.

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Orthotopic Mouse Model

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