February 2nd, 2014
•Prophylactic and therapeutic vaccination often fails to stimulate strong immune responses due to week drainage of the vaccine to lymph nodes and consequently poor involvement of immune cells. By direct injection of vaccine to lymph nodes, so-called intralymphatic injection, vaccine efficacy can be strongly improved and vaccine doses can be reduced.
Tags
Related Videos
Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model
Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Measuring Local Anaphylaxis in Mice
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved