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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

DOI :

10.3791/53084-v

10:10 min

October 5th, 2015

October 5th, 2015

18,383 Views

1Department of Clinical and Experimental Medicine, Linköping University, 2Department of Medicine, Karolinska Institute

Human tuberculosis infection is a complex process, which is difficult to model in vitro. Here we describe a novel 3D human lung tissue model that recapitulates the dynamics that occur during infection, including the migration of immune cells and early granuloma formation in a physiological environment.

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3D Human Lung Tissue Model

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