Results: Representative Micrometastasis Evaluation After Murine Tumor Cell Injection
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Conclusion
Transcript
Experimental and clinical evidence show that liver ischemia reperfusion can increase the formation of metastatic foci by circulating cancer cells and the growth of micrometastatic disease. This reproducible murine model permits the relevant study
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We describe in detail a clinically relevant colorectal cancer liver metastases (CRLM) tumor model and the influence of liver ischemia reperfusion (I/R) in tumor growth and metastasis. This model can help to better understand the mechanisms underlying surgery-induced promotion of liver metastatic growth.