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Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo

DOI :

10.3791/62850-v

7:19 min

August 4th, 2021

August 4th, 2021

3,264 Views

1College of Medicine, Central Michigan University, 2Biochemistry, Cell and Molecular Biology Program, Central Michigan University, 3Neuroscience Program, Central Michigan University

Bioluminescence-light emitted by a luciferase enzyme oxidizing a small-molecule substrate, a luciferin-can be harnessed to activate photosensory proteins, thereby adding another dimension to light stimulation and enabling the manipulation of a multitude of light-mediated functions in cells across temporal and spatial scales.

Tags

Bioluminescent Optogenetics

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