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JoVE Journal

Medicine

This content is Free Access.

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

818 Views

06:29 min

October 20th, 2023

October 20th, 2023

820 Views

0:00

Introduction

0:05

Surgical Setup and Animal Preparation

1:29

Surgery and Ischemia

3:56

Tissue Collection and Processing for Histology

5:47

Results: Post-IRI Analysis of Small Intestine

Transcript

We describe how to generate a widely used surgical model of intestinal ischemia-reperfusion injury (IRI) in rodents. The procedure involves occlusion of the superior mesenteric artery followed by the restoration of blood flow. This model is useful for studies investigating occlusive causes of intestinal IRI in both veterinary and human medicine.

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