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In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology

2.2K Views

13:17 min

September 29th, 2023

DOI :

10.3791/64902-v

September 29th, 2023


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Photocontrolled Compounds

Chapters in this video

0:00

Introduction

1:22

IC50 Evaluation for LMB002 ("ring-closed" and "ring-open" forms) Using 2D and 3D LLC Cell Cultures

3:06

2D Cell Culture Experiment—Adding the Compounds (Day 2)

4:14

2D Cell Culture Experiment—Staining and Imaging (Days 2–5)

4:45

3D Cell Culture Experiment

5:46

Determination of Photoswitching Efficiency in a Tissue Surrogate

7:46

In Vivo Anticancer Efficacy Determination

9:39

Representative Results

12:40

Conclusion

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