Name: effects of mindfulness training combined with tai chi in patients with diabetic peripheral neuropathy
Uploaded: 2023-07-14T12:30:00.000+00:00
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Description: Watch this Scientific Journal Video about Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise at JoVE.com

本研究得到了成都中医药大学附属医院科技发展基金（20HL01）和四川省干部健康研究项目（2023-505）的资助。这项研究得到了四川省干部卫生厅（川赣颜2023-505）的资助。

本研究严格遵循尊重道德、仁慈正义的原则。每组30名受试者，共90例。本课题已获成都中医药大学附属医院伦理委员会批准（2021KL-040）。从纳入本研究的患者那里获得知情同意。
1. 研究对象
<ol><li>采用便捷抽样法，选择成都的3个社区。</li>
	<li>从三个社区招募 T2DM 周围神经病变患者。</li>
	<li>使用以下纳入标准。<ol><li>包括 40-75 岁的患者。</li>
		<li>包括诊断为 DPN 的患者。</li>
		<li>包括可以进行中等强度有氧运动的患者。</li>
		<li>包括在研究期间未使用任何其他补充或综合疗法的患者。</li>
	</ol></li>
	<li>排除具有以下疾病的患者：由其他疾病引起的神经系统疾病，如颈椎和腰椎病、脑血管疾病、格林-巴利综合征和血管病变;孕妇或哺乳期妇女;精神异常无法合作。</li>
	<li>抽签将三个社区的患者随机分配到对照组 （CG）、太极组 （TCG） 和正念与太极组 （MTCG）。</li>
</ol>2. 方法一：CG的练习方法
<ol><li>进行 3 次集体健康教育课程，每次持续 40 分钟。 注：健康教育内容主要包括糖尿病饮食、运动、药物、血糖监测、足部护理、足部并发症的预防和护理12。三个小组分别进行健康教育。</li>
</ol>3. 方法二：TCG的练习方法
<ol><li>选择一个公共、安静的区域来练习 24 种简化的太极拳33 之一。 注：实施方法：分为热身、训练、放松3个部分。集中锻炼每周进行 3 次，每次 60 分钟，持续 12 周。</li>
	<li>指导参与者完成两组内收肌（即内旋）、外展肌（即外旋）、腘绳肌（即单腿僵硬向前弯曲伸展）、臀肌（即髋关节屈曲和伸展）和踝关节定向（即脚踝旋转）动态伸展练习 10 分钟，作为热身准备练习的一部分34.</li>
	<li>在太极拳教练的指导下，让参与者随着太极音乐表演太极拳动作40分钟。 注：太极拳的动作包括：从两侧野马的鬃毛开始，白鹤展开翅膀，两侧刷膝盖和扭步，弹奏琵琶，击退猴子，抓住鸟的尾巴，单鞭，挥手如云，高拍马，右脚后跟踢，双拳击打对手的耳朵， 左脚跟转身踢腿，蛇匍匐而下，玉女编织梭子，针刺海底，闪臂转身，向下偏转，招架出拳，双手交叉，合拢33。</li>
	<li>做上下肢放松练习和呼吸调节练习 10 分钟作为放松练习35. 注意：首先，站立并反复摇晃肩膀和手臂。然后捶打和按摩腿部。最后，坐下并调整呼吸模式。</li>
</ol>4. 方法三：母婴传播的实践方法
<ol><li>选择一个开放安静的地方铺上瑜伽垫坐下。 注意：正念训练与太极拳练习相结合，每周进行 3 次，每次 60 分钟，共 12 周。鼓励受试者每天在家中坚持正念练习。目的是将正念融入日常生活。</li>
	<li>开始正念训练与太极拳相结合。 注：具体培训安排见 表1。<ol><li>正念训练与太极拳练习方法相结合<ol><li>正念冥想：<ol><li>坐在瑜伽垫上。</li>
				<li>慢慢吸气和呼气 3-4 次深呼吸。</li>
				<li>感觉空气进入鼻子，充满胸部和腹部，并呼出身体。</li>
				<li>将呼吸节律调整回正常。不要试图控制呼吸。</li>
				<li>将呼吸节律调整回正常。不要试图控制呼吸。</li>
				<li>注意呼吸、身体、声音、思想、情绪等，慢慢放松身体。</li>
			</ol></li>
			<li>正念身体扫描：<ol><li>仰卧在瑜伽垫上，双腿自然分开，眼睛几乎闭不上，手臂自然坐下，不接触身体。</li>
				<li>注意整个身体的感觉，从脚趾到大脑。在进行正念身体扫描练习时，选择坐着以防止入睡。</li>
			</ol></li>
			<li>正念运动（太极拳）：<ol><li>专注于太极拳的每一个动作。 注意：在太极拳练习中，用温和的语言引导练习者感受腿部肌肉交替收缩和放松带来的压力和放松，感受脚与地面接触的感觉。</li>
				<li>尽量在任何时候都保持正念状态。</li>
				<li>当腿部肌肉交替收缩和放松时，感到压力和放松。同时，感受双脚触地的感觉。</li>
			</ol></li>
		</ol></li>
	</ol></li>
	<li>结束活动<ol><li>做上下肢放松练习和呼吸调节练习 10 分钟作为放松练习35. 注意：首先，站立并反复摇晃肩膀和手臂。然后捶打和按摩腿部。最后，坐下并调整呼吸。</li>
		<li>坐在冥想中，不要对进入头脑的各种想法做出任何判断，并始终接受这些概念。</li>
		<li>将每项日常任务（例如刷牙、淋浴或做饭）转换为正念练习。</li>
	</ol></li>
</ol>5. 收集信息
<ol><li>选派数据采集人员，开展统一培训。 注意：分别在干预之前和之后收集数据。数据收集者全权负责数据收集，对分组分配不知情，以减少数据收集者的主观偏见。<ol><li>收集多伦多临床评分系统 （TCSS）36、视觉模拟量表 （VAS）37、正念和注意力意识量表 （MAAS）38、糖尿病特异性生活质量量表 （DSQL）39 和血清肿瘤坏死因子-α （TNF-α） 水平的数据。</li>
	</ol></li>
	<li>在研究开始之前，由研究团队成员讨论并决定每个指标的详细收集标准。</li>
	<li>向受试者彻底解释量表的含义、每个项目的含义以及如何使用它。</li>
	<li>帮助参与者就位，进行身体评估，并详细记录。</li>
	<li>从附近医院的参与者那里收集血液样本，然后立即将其送到实验室。</li>
	<li>及时检查所收集信息的准确性和完整性。</li>
</ol>6. 统计分析
<ol><li>使用任何统计分析软件收集和分析数据。 注：在本研究中，使用了SPSS 24.0。</li>
	<li>通过平均值、频率或成分比率的平均值±标准误差来描述数据。</li>
	<li>使用卡方检验、方差分析、Kruskal Wallis H 检验、配对 t 检验和 Wilcoxon 符号秩检验。</li>
	<li>在每个样品的所有时间点至少读取三次读数。</li>
</ol>

太极拳配合正念训练治疗糖尿病周围神经病变

作者没有什么可透露的。

以前的许多研究都报道了如何应用太极拳来治疗和康复慢性疾病40,41。虽然太极拳在慢性病的治疗和康复方面显示出积极的作用，但真正实现身心锻炼对于增强太极拳的效果至关重要。 本研究将太极拳与正念训练相结合，成功提高了太极拳的练习效果，确实实现了身心运动。
这项研究成功地将正念训练融入了太极拳。 参与者必须?...

糖尿病 （DM） 是全球严重的健康问题，影响着全球数百万人1.国际糖尿病联合会 （IDF） 显示，到 2045 年，糖尿病的患病率可能会增加至 12.2%2。2 型糖尿病 （T2DM） 约占DM 2 的 90%。T2DM 患者，尤其是那些难以控制血糖水平的患者，可能会出现不良并发症，包括大血管疾病、微血管病和糖尿病周围神经病变 （DPN）3。DPN 是一种普遍存在的微血管并发症，随着时间的推移，至少 50% 的 DM 患者会出现 DPN 体征和症状4。不幸的是，DPN 经常被忽视，患者的实际数字远高于大多数病例报告的数字2。
血糖控制不佳的患者容易发生起病隐匿的 DPN。DPN 的初始症状通常不明显，这使得患者很容易忽视病情。当出现明显的症状和功能障碍时，已造成不可逆的神经损伤5.DPN 具有复杂的临床表现。患者患有长期代谢紊乱和氧化应激损伤。这可能导致对称性肢体麻木、疼痛或感觉异常 6,7。随着疾病的进展，神经和血管损伤进一步加重，最终导致不可逆的组织损伤8.糖尿病足溃疡和截肢的发生率与 DPN9 的死亡率相关。此外，由于 DPN 的症状经常持续存在，许多患者会出现抑郁、睡眠障碍和活动受限，导致整体生活质量下降甚至残疾10。
目前，除了血糖控制和药物治疗外，生活方式干预（包括运动、饮食、心理治疗等）是公认的对 DPN 患者的有效治疗方法11。根据美国糖尿病协会（ADA）的说法，“有价值的运动对所有糖尿病患者都有好处”。例如，它可以改善糖脂代谢和胰岛素抵抗1。研究表明，运动可以改善 DPN12,13 患者的代谢、血管损伤和神经功能。然而，DPN 患者由于缺乏运动、疼痛和对足部受伤的恐惧而不愿运动。
根据恐惧回避模型 （FAM），糖尿病周围神经病变 （DPN） 患者的身体不适和日常活动受限会降低他们的社交互动能力，进而导致焦虑和抑郁等负面情绪反应14.相反，负面情绪会影响血糖控制并增加并发症的发生率15,16,17,18。因此，DPN推荐采用身心疗法，其重点是思想、情绪、身体和行为之间的相互作用。目的是实现身体和心灵的平衡。
太极拳是中国传统的身心运动。太极拳因其独特的运动方式和对疾病的治疗作用而受到世界学者的广泛关注。在国际期刊上发表的多项高质量临床试验证实了太极拳对帕金森病19、中风20、代谢综合征21、膝关节炎22、乳腺癌23等慢性病的治疗和康复的有效性。太极拳属于一类中等强度的有氧运动，它使用连续的身体螺旋运动和调节呼吸来提高有氧能力、肌肉力量、平衡和运动能力。中医认为太极拳可以平衡阴阳，跑气流血，放松经络24。对于DPN患者来说，这是一种合适的运动形式。许多研究发现，太极拳可以改善胰岛素抵抗和血脂，并降低焦虑和抑郁的发生率25,26。此外，太极拳可以改善T2DM 27患者的生活质量并降低体重指数。
正念训练是另一种突出的身心干预，其重点是培养一种有意识的、即时的、非评判性的体验意识28.它有助于增强对当前体验的关注，包括思想、感觉、呼吸和身体感觉。Zeidan的研究发现，正念训练可以使患者更客观地评估不适并改善自我调节29。Wielgosz的研究表明，运动干预的最大问题是依从性差，这可以通过在运动30中增加正念训练来解决。正念训练结合运动可有效提高患者运动意愿，增加运动时间和频率，促进患者在活动中感知身体感觉。
同时，运动结合正念训练，可以拓宽患者的视野，增强对自己的了解。这有助于身体变得更加灵活、放松和平衡，有效缓解患者的负面体验。正念训练的概念与太极拳的“形灵合一”的理念是一致的。 由于感觉功能受损，大多数DPN患者经常从大脑提供的脚部接收错误信息31。正念训练可以通过心理调节和神经调节来增强运动的效果32.因此，本研究旨在验证正念训练结合太极拳的可行性，并探讨其对 DPN 患者的影响。

<table><tbody><tr><td>SPSS 24.0&amp;nbsp;</td><td>IBM</td><td>version&amp;nbsp;24.0&amp;nbsp;</td><td>Statistical analysis</td></tr></tbody></table>

effects of mindfulness training combined with tai chi in patients with diabetic peripheral neuropathy

糖尿病周围神经病变（DPN）是糖尿病最常见的慢性并发症之一。其关键的治疗方法之一是身心锻炼。最近，研究了各种运动方式，包括踏步、阻力、有氧运动、平衡和全身振动，以构建最适合 DPN 患者的运动形式。本研究的目的是描述正念训练与太极拳相结合的标准方案。 采用便利抽样法从3个社区中选取90例符合纳入和排除标准的DPN患者。将3个社区随机分为对照组（CG）、太极拳组（TCG）和正念训练联合太极拳组（MTCG）。CG每月接受一次常规健康教育指导，共3次。根据CG，TCG练习了三次太极拳;MTCG每周接受正念训练和太极拳练习，共计12周。采用多伦多临床评分系统（TCSS）、正念注意力意识量表（MAAS）、视觉模拟量表（VAS）、糖尿病特异性生活质量量表（DSQL）和肿瘤坏死因子-α评估受试者的临床症状、神经功能、注意力意识水平、疼痛和生活质量。总的来说，在太极拳中加入正念训练，有效增强了太极拳的运动效果，因此，正念训练与太极拳相结合，是值得推广和应用的。

在这项研究中，有 7 人未能完成试验。所有必要的数据都是从完成试验的83个人中收集的。有38名女性和45名男性。年龄从44岁到75岁不等，平均年龄为（60.57+8.76）。DM 可能持续 4 到 22 年，平均为 14.10 + 4.85 年。DPN 持续了 1 年到 15 年不等，平均为 5.76 + 2.78 年。三组的一般数据差异无统计学意义（p>0.05）。
干预后，3组患者TCSS评分差异有统计学意义（P < 0.001）（见?...

Watch this Scientific Journal Video about Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise at JoVE.com

作者聚焦：将太极拳与正念训练相结合，实现有效的身心锻炼 

在研究运动治疗糖尿病周围神经病变 （DPN） 时，实现身心锻炼至关重要。本研究提出了一种正念训练与太极拳相结合的方案，以实现身心锻炼。

正念训练联合太极拳对糖尿病周围神经病变患者的影响

Diabetic peripheral neuropathy (DPN) is one of the most prevalent chronic complications of diabetes. One of its crucial therapy approaches is mind-body ...

我们的研究集中在中国传统运动太极拳上，我们正在探索正念训练与太极拳相结合作为治疗糖尿病周围神经病变的身心锻炼的可能性和有效性。确保受试者每周完成三次强化训练是本研究的一项重要挑战。我们的研究表明，太极拳可以与正念训练很好地结合在一起。我们概述了将正念训练与太极拳相结合的步骤。 它将为太极拳的未来发展铺平道路，使这项传统运动对练习者更具吸引力和益处。未来，我们将专注于正念训练与太极拳相结合在其他慢性疾病中的应用。我们还将努力推广与太极拳相结合的正念训练。

effects-mindfulness-training-combined-with-tai-chi-patients-with

Research

JoVE Journal

Medicine

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

1.6K 次观看.  Hospital of Chengdu University of Traditional Chinese Medicine. 我们的研究集中在中国传统运动太极拳上，我们正在探索正念训练与太极拳相结合作为治疗糖尿病周围神经病变的身心锻炼的可能性和有效性。确保受试者每周完成三次强化训练是本研究的一项重要挑战。我们的研究表明，太极拳可以与正念训练很好地结合在一起。我们概述了将正念训练与太极拳相结合的步骤。 它将为太极拳的未来发展铺平道路，使这项传统运动对练...

视频: 作者聚焦：将太极拳与正念训练相结合，实现有效的身心锻炼 

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults

Adapted tango dancing improves mobility and balance in older adults and additional populations with balance impairments. It is composed of very simple step elements. Adapted tango involves movement initiation and cessation, multi-directional perturbations, varied speeds and rhythms. Focus on foot placement, whole body coordination, and attention to partner, path of movement, and aesthetics likely underlie adapted tango&#8217;s demonstrated efficacy for improving mobility and balance. In this paper, we describe the methodology to disseminate the adapted tango teaching methods to dance instructor trainees and to implement the adapted tango by the trainees in the community for older adults and individuals with Parkinson&#8217;s Disease (PD). Efficacy in improving mobility (measured with the Timed Up and Go, Tandem stance, Berg Balance Scale, Gait Speed and 30 sec chair stand), safety and fidelity of the program is maximized through targeted instructor and volunteer training and a structured detailed syllabus outlining class practices and progression.

Adapted tango has demonstrated efficacy for improving mobility and balance. We describe the dissemination of adapted tango teaching methods to dance instructor trainees and the implementation of adapted tango by the trainees in the community for improving mobility and balance in older adults and individuals with Parkinson&#8217;s disease.

以社区为基础改编的探戈舞的个人与帕金森氏病和老年人

Adapted tango dancing improves mobility and balance in older adults and additional populations with balance impairments. It is composed of very simple ...

科研

行为学

Mindfulness in Motion (MIM): An Onsite Mindfulness Based Intervention (MBI) for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

A pragmatic mindfulness intervention to benefit personnel working in chronically high-stress environments, delivered onsite during the workday, is timely and valuable to employee and employer alike. Mindfulness in Motion (MIM) is a Mindfulness Based Intervention (MBI) offered as a modified, less time intensive method (compared to Mindfulness-Based Stress Reduction), delivered onsite, during work, and intends to enable busy working adults to experience the benefits of mindfulness. It teaches mindful awareness principles, rehearses mindfulness as a group, emphasizes the use of gentle yoga stretches, and utilizes relaxing music in the background of both the group sessions and individual mindfulness practice. MIM is delivered in a group format, for 1 hr/week/8 weeks. CDs and a DVD are provided to facilitate individual practice. The yoga movement is emphasized in the protocol to facilitate a quieting of the mind. The music is included for participants to associate the relaxed state experienced in the group session with their individual practice. To determine the intervention feasibility/efficacy we conducted a randomized wait-list control group in Intensive Care Units (ICUs). ICUs represent a high-stress work environment where personnel experience chronic exposure to catastrophic situations as they care for seriously injured/ill patients. Despite high levels of work-related stress, few interventions have been developed and delivered onsite for such environments. The intervention is delivered on site in the ICU, during work hours, with participants receiving time release to attend sessions. The intervention is well received with 97% retention rate. Work engagement and resiliency increase significantly in the intervention group, compared to the wait-list control group, while participant respiration rates decrease significantly pre-post in 6/8 of the weekly sessions. Participants value institutional support, relaxing music, and the instructor as pivotal to program success. This provides evidence that MIM is feasible, well accepted, and can be effectively implemented in a chronically high-stress work environment.

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

The Mindfulness in Motion (MIM) protocol offers a pragmatic Mindfulness Based Intervention (MBI) on-site, for persons working in chronically high-stress work environments that significantly increases resiliency and work engagement. The protocol has proven feasible, beneficial, and is easily adaptable to other high-stress workplaces.

正念的运动 （MIM）:一种基于现场干预正念（MBI）用于长期的高压力的工作环境，以增加弹性和工作投入

A pragmatic mindfulness intervention to benefit personnel working in chronically high-stress environments, delivered onsite during the workday, is timely ...

Using Wavelet Entropy to Demonstrate how Mindfulness Practice Increases Coordination between Irregular Cerebral and Cardiac Activities

In both the East and West, traditional teachings say that the mind and heart are somehow closely correlated, especially during spiritual practice. One difficulty in proving this objectively is that the natures of brain and heart activities are quite different. In this paper, we propose a methodology that uses wavelet entropy to measure the chaotic levels of both electroencephalogram (EEG) and electrocardiogram (ECG) data and show how this may be used to explore the potential coordination between the mind and heart under different experimental conditions. Furthermore, Statistical Parametric Mapping (SPM) was used to identify the brain regions in which the EEG wavelet entropy was the most affected by the experimental conditions. As an illustration, the EEG and ECG were recorded under two different conditions (normal rest and mindful breathing) at the beginning of an 8-week standard Mindfulness-based Stress Reduction (MBSR) training course (pretest) and after the course (posttest). Using the proposed method, the results consistently showed that the wavelet entropy of the brain EEG decreased during the MBSR mindful breathing state as compared to that during the closed-eye resting state. Similarly, a lower wavelet entropy of heartrate was found during MBSR mindful breathing. However, no difference in wavelet entropy during MBSR mindful breathing was found between the pretest and posttest. No correlation was observed between the entropy of brain waves and the entropy of heartrate during normal rest in all participants, whereas a significant correlation was observed during MBSR mindful breathing. Additionally, the most well-correlated brain regions were located in the central areas of the brain. This study provides a methodology for the establishment of evidence that mindfulness practice (i.e., mindful breathing) may increase the coordination between mind and heart activities.

This manuscript describes how to use the wavelet entropy index to analyze high-density electroencephalography (EEG) and electrocardiography (ECG) data. We show that the irregularity of cerebral and cardiac activities became more coordinated during mindfulness-based stress reduction practice.

使用小波熵来证明正念练习如何增加不规则脑与心脏活动之间的协调

In both the East and West, traditional teachings say that the mind and heart are somehow closely correlated, especially during spiritual practice. One ...

Alleviation of Diabetic Tendon Injury via Activation of Tendon Fibroblasts Autophagy under Berberine Treatment

Berberine (BBR) is an isoquinoline alkaloid isolated from Coptis chinensis and possesses valuable pharmacological activities, including anti-inflammatory, anti-tumor, and alleviating several complications of type 2 diabetes mellitus (T2DM). However, the role of BBR in regulating diabetic tendon injury remains poorly understood. In this study, a rat model of T2DM was constructed, and cell apoptosis and autophagy were assessed in tendon tissues after BBR treatment through TdT-Mediated dUTP nick-end labeling (TUNEL) assay and immunohistochemical analysis. Tendon fibroblasts were obtained from the rat Achilles tendon, and the role of BBR in regulating cell apoptosis, the production of inflammatory cytokines, and autophagy activation were assessed using flow cytometry, quantitative real-time PCR (qRT-PCR), and western blot analysis. We demonstrated that BBR treatment significantly increased autophagy activation and decreased cell apoptosis in tendon tissues of T2DM rats. In tendon fibroblasts, BBR repressed High glucose (HG)-induced cell apoptosis and production of proinflammatory cytokines. HG treatment resulted in a decrease of autophagy activation in tendon fibroblasts, whereas BBR restored autophagy activation. More important, pharmacological inhibition of autophagy by 3-MA weakened the protective effects of BBR against HG-induced tendon fibroblasts injury. Taken together, the current results demonstrate that BBR helps relieve diabetic tendon injury by activating autophagy of tendon fibroblasts.

Berberine (BBR) is an isoquinoline alkaloid isolated from Coptis chinensis and possesses valuable pharmacological activities, including anti-inflammatory, ...

生物化学

针灸慢性缺氧小鼠的认知改善

Acupuncture Treatment in a Mouse Model of Chronic Hypoxia-Induced Cognitive Dysfunction

The treatment of central nervous disorders has consistently posed significant challenges to the medical field. Acupuncture, a non-pharmacological practice rooted in traditional Chinese medicine, entails the insertion of fine needles into precise points on the body and is commonly employed for the management of diverse conditions. Recently, acupuncture has emerged as a promising therapeutic intervention for a range of neurological diseases, including anxiety and respiratory disorders. However, the potential of acupuncture in treating cognitive dysfunction induced by chronic hypoxia has not yet been explored. This paper presents a comprehensive protocol for establishing a mouse model of chronic hypoxia-induced cognitive impairment, administering mild anesthesia, performing acupuncture treatment, and assessing behavioral changes and memory abilities using open field tests and water mazes. The step-by-step protocol provides detailed instructions on accurately locating and positioning acupoints and needles for cognitive improvement. By employing this protocol, researchers can conduct systematic studies to thoroughly evaluate the therapeutic potential of acupuncture for cognitive dysfunction.

作者聚焦:改进增强小鼠针刺研究的麻醉方案

Here, we describe a protocol for implementing mild anesthesia and acupuncture treatment on a chronic hypoxia mouse model and conducting behavioral tests to assess the cognitive alterations post-treatment.

针灸治疗慢性缺氧诱导认知功能障碍小鼠模型

The treatment of central nervous disorders has consistently posed significant challenges to the medical field. Acupuncture, a non-pharmacological practice ...

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

With the development of society and the economy, the incidence of diabetic foot ulcers continues to increase. Currently, conventional debridement with dressing changes, hyperbaric oxygen, and vacuum sealing drainage are the main conservative treatments in clinical practice, and large wounds often require skin grafts or skin flap grafts. However, the treatment effects are not ideal, and many complications exist. Due to its complex pathogenesis, long treatment time, significant associated difficulties, and high disability rate, diabetic foot ulcers cause a heavy burden to patients, society, and medical care. According to our previous study, the pharmacological effects of human umbilical cord blood stem cells include nonspecific immune regulation; increased secretion of growth factors, vasoactive factors, and anti-inflammatory factors; enhanced anti-infectious ability of the human body; elimination of inflammation; and promotion of angiogenesis and ulcer healing. These effects suggest stem cells may be useful as an autologous or allogeneic treatment for refractory wounds. Therefore, we are conducting a clinical trial to treat refractory diabetic wounds with human umbilical cord stem cells in our clinic for diabetic foot ulcer patients who meet the inclusion criteria.

The present protocol describes a prospective, randomized, controlled clinical study that evaluates a human umbilical cord mesenchymal stem cell injection for the treatment of chronic diabetic foot ulcers.

人脐带间充质干细胞注射治疗糖尿病足溃疡的前瞻性、随机和对照研究

With the development of society and the economy, the incidence of diabetic foot ulcers continues to increase. Currently, conventional debridement with ...

生物工程

Combining Behavior and EEG to Study the Effects of Mindfulness Meditation on Episodic Memory

Although there has been recent interest in how mindfulness meditation can affect episodic memory as well as brain structure and function, no study has examined the behavioral and neural effects of mindfulness meditation on episodic memory. Here we present a protocol that combines mindfulness meditation training, an episodic memory task, and EEG to examine how mindfulness meditation changes behavioral performance and the neural correlates of episodic memory. Subjects in a mindfulness meditation experimental group were compared to a waitlist control group. Subjects in the mindfulness meditation experimental group spent four weeks training and practicing mindfulness meditation. Mindfulness was measured before and after training using the Five Facet Mindfulness Questionnaire (FFMQ). Episodic memory was measured before and after training using a source recognition task. During the retrieval phase of the source recognition task, EEG was recorded. The results showed that mindfulness, source recognition behavioral performance, and EEG theta power in right frontal and left parietal channels increased following mindfulness meditation training. In addition, increases in mindfulness correlated with increases in theta power in right frontal channels. Therefore, results obtained from combining mindfulness meditation training, an episodic memory task, and EEG reveal the behavioral and neural effects of mindfulness meditation on episodic memory.

Here we present a protocol for combining mindfulness meditation training, an episodic memory task, and EEG to understand the behavioral and neural effects of mindfulness meditation on episodic memory.

结合行为和脑电图研究正念冥想对情景记忆的影响

Although there has been recent interest in how mindfulness meditation can affect episodic memory as well as brain structure and function, no study has ...

神经科学

Scalp Acupuncture Synchronizing Dual Task Gait for Enhancing Prefrontal Cortex Response

Studies have shown that motor-cognitive dual task can greatly improve motor/cognitive function. However, the therapeutic effect of motor-cognitive dual task is still limited. How to improve dual-task performance is the key to solving this problem. Scalp acupuncture is a non-drug intervention method of traditional Chinese medicine to treat brain-derived diseases by acupuncturing the corresponding projection area of cerebral cortex function on the scalp. Studies have shown that scalp acupuncture helps improve neuronal damage and cognitive dysfunction and plays a neuroprotective function in central nervous system diseases. However, no relevant studies have discussed the synergistic gain effect of motor-cognitive dual task and scalp acupuncture. Therefore, this protocol aims to demonstrate the standardized operation of scalp acupuncture synchronizing motor-cognitive dual task and motor-cognitive dual task and compares the differences between these two tasks in healthy subjects through a randomized cross-over trial. This protocol initially revealed the possible influence mechanism of scalp acupuncture synchronizing motor-cognitive dual task on cognitive performance, gait control, and cortical brain function, which can provide new ideas and a theoretical basis for clinical exploration of new and effective non-drug treatment of integrated Chinese and Western medicine.

This protocol demonstrates the standardized procedure of scalp acupuncture synchronizing motor-cognitive dual task and motor-cognitive dual task. This can provide an important reference for the clinical exploration of the new and effective non-drug treatment of integrated Chinese and Western medicine.

头皮针灸同步双任务步态增强前额叶皮层反应

Studies have shown that motor-cognitive dual task can greatly improve motor/cognitive function. However, the therapeutic effect of motor-cognitive dual ...

正念训练联合太极拳对糖尿病周围神经病变患者的影响

副本

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探索更多视频

此视频中的章节

以社区为基础改编的探戈舞的个人与帕金森氏病和老年人

正念的运动（MIM）:一种基于现场干预正念（MBI）用于长期的高压力的工作环境，以增加弹性和工作投入

使用小波熵来证明正念练习如何增加不规则脑与心脏活动之间的协调

Alleviation of Diabetic Tendon Injury via Activation of Tendon Fibroblasts Autophagy under Berberine Treatment

针灸治疗慢性缺氧诱导认知功能障碍小鼠模型

针灸治疗慢性缺氧诱导认知功能障碍小鼠模型

针灸治疗慢性缺氧诱导认知功能障碍小鼠模型

人脐带间充质干细胞注射治疗糖尿病足溃疡的前瞻性、随机和对照研究

结合行为和脑电图研究正念冥想对情景记忆的影响

头皮针灸同步双任务步态增强前额叶皮层反应

正念训练联合太极拳对糖尿病周围神经病变患者的影响

副本

摘要

探索更多视频

此视频中的章节

以社区为基础改编的探戈舞的个人与帕金森氏病和老年人

正念的运动 （MIM）:一种基于现场干预正念（MBI）用于长期的高压力的工作环境，以增加弹性和工作投入

使用小波熵来证明正念练习如何增加不规则脑与心脏活动之间的协调

Alleviation of Diabetic Tendon Injury via Activation of Tendon Fibroblasts Autophagy under Berberine Treatment

针灸治疗慢性缺氧诱导认知功能障碍小鼠模型

针灸治疗慢性缺氧诱导认知功能障碍小鼠模型

针灸治疗慢性缺氧诱导认知功能障碍小鼠模型

人脐带间充质干细胞注射治疗糖尿病足溃疡的前瞻性、随机和对照研究

结合行为和脑电图研究正念冥想对情景记忆的影响

头皮针灸同步双任务步态增强前额叶皮层反应

正念的运动（MIM）:一种基于现场干预正念（MBI）用于长期的高压力的工作环境，以增加弹性和工作投入