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Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

DOI :

10.3791/64677-v

February 17th, 2023

February 17th, 2023

730 Views

1State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, 2Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3Laboratory of Molecular Engineering and Nanomedicine, Dr. Li Dak-Sum Research Centre, The University of Hong Kong

This protocol describes the fabrication and characterization of a photoresponsive prodrug-dye nanoassembly. The methodology for drug release from the nanoparticles by light-triggered disassembly, including the light irradiation setup, is explicitly described. The drugs released from the nanoparticles following light irradiation exhibited excellent anti-proliferation effects on human colorectal tumor cells.

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Keywords Prodrug dye Nanoassemblies

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